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Alex Chompff

Consensus Molecular Subtype Classification Feasible Using Preoperative Biopsies

Skip to content The CRC Digest Consensus Molecular Subtype Classification Feasible Using Preoperative Biopsies A prospective pilot study evaluated the feasibility of consensus molecular subtype classification of colorectal cancer using preoperative biopsy specimens, examining RNA yield, quality, and concordance between different biopsy forceps. (Journal of the Anus, Rectum and Colon)

Unexplained Microcytosis in 40-Year-Old: Missed Opportunity for Early Diagnosis

Skip to content The CRC Digest Unexplained Microcytosis in 40-Year-Old: Missed Opportunity for Early Diagnosis A case report highlights how isolated microcytosis and iron deficiency in a 40-year-old male with morbid obesity was a missed early indicator of colorectal cancer. (South Dakota Medicine) This content is informational only and does

Medicaid Expansion Linked to Lower Mortality in Metastatic CRC

Skip to content The CRC Digest ♥ LIVING WITH CRC Medicaid Expansion Linked to Lower Mortality in Metastatic CRC A SEER database analysis found that Medicaid expansion was associated with decreased mortality in patients younger than 65 diagnosed with colorectal cancer and synchronous liver metastasis. (Annals of Surgery) This content is

First Patient Dosed in Phase 2 Trial of Oral KRAS G12D Inhibitor

Skip to content The CRC Digest ▸ TREATMENT First Patient Dosed in Phase 2 Trial of Oral KRAS G12D Inhibitor Verastem Oncology has dosed the first patient in a phase 2 registration-directed trial of VS-7375, an oral KRAS G12D inhibitor, for KRAS G12D-mutated metastatic colorectal cancer. (BioSpace) This content is informational

Liquid Biopsy Guides HER2 Therapy Rechallenge in Metastatic CRC

Skip to content The CRC Digest ▸ TREATMENT Liquid Biopsy Guides HER2 Therapy Rechallenge in Metastatic CRC A study found that liquid biopsy can guide rechallenge with anti-HER2 therapy in patients with HER2-amplified metastatic colorectal cancer. (JCO Precision Oncology) This content is informational only and does not constitute medical advice. Always

Dynamic ctDNA Methylation Monitoring Guides Postoperative Surveillance in FIND Trial

Skip to content The CRC Digest ◆ TRIAL DATA Dynamic ctDNA Methylation Monitoring Guides Postoperative Surveillance in FIND Trial A prospective, randomized phase III trial tested whether circulating tumor DNA methylation monitoring can guide postoperative surveillance in nonmetastatic colorectal cancer patients. (Journal of Clinical Oncology) This content is informational only and

CRC Research Update — July 31, 2026

Today's colorectal cancer research highlights

Physical activity and sedentary behavior linked to cortisol rhythms in CRC survivors up to 1 year after treatment

Skip to content The CRC Digest ♥ LIVING WITH CRC Physical activity and sedentary behavior linked to cortisol rhythms in CRC survivors up to 1 year after treatment Among 74 CRC survivors, accelerometer-assessed sedentary time and physical activity were longitudinally associated with diurnal cortisol patterns, which may influence fatigue, mood, and

Case report: BRAF V600E-mutant metastatic CRC patient achieves prolonged response to combined BRAF and MEK inhibition

Skip to content The CRC Digest ▸ TREATMENT Case report: BRAF V600E-mutant metastatic CRC patient achieves prolonged response to combined BRAF and MEK inhibition A 60-year-old male patient diagnosed in 2019 with BRAF-mutant metastatic CRC and peritoneal metastases experienced an extraordinary response to MEK inhibitor-based treatment. (Frontiers in Oncology) This content

Gut microbiome signatures show promise for non-invasive detection of colorectal neoplasia

Skip to content The CRC Digest ▪ SCREENING Gut microbiome signatures show promise for non-invasive detection of colorectal neoplasia Multinational metagenomic studies have identified reproducible microbial signatures associated with CRC, offering a potential alternative to current stool-based tests that have limited sensitivity for adenoma detection. (Journal of Gastroenterology) This content is