Blood-Based CRC Screening Tests Show Promise but Have Key Limitations

▪ SCREENING

Three blood-based CRC screening tests (Epi proColon, Shield, and the Freenome test) have completed large validation studies, but all show low sensitivity for advanced precancerous lesions, low rates of follow-up colonoscopy after an abnormal test, and concerns about cost-effectiveness. (Gastrointest Endosc Clin N Am)