Researchers used paired patient-derived normal and tumor colorectal organoids to investigate how calcitriol (the active vitamin D metabolite) modulates chemotherapy response. Dose-response analyses revealed marked interpatient variability, with SN38 being more potent than 5-fluorouracil and oxaliplatin. (International Journal of Biological Sciences)
Calcitriol Modulates Age-Dependent Drug Response in Patient-Derived Colorectal Organoids
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