The CRC Digest

Curated CRC research — accessible, accurate, actionable

Saturday, March 14, 2026

IMPORTANT: The CRC Digest curates and summarizes publicly available research for informational and educational purposes only. Nothing in this newsletter constitutes medical advice, diagnosis, or treatment recommendation. The information provided should not be used as a substitute for professional medical advice. Always seek the guidance of your physician or other qualified health provider with any questions regarding a medical condition or treatment. Content is generated with AI assistance and reviewed by the editorial team. We are not medical professionals. Individual results, treatments, and outcomes vary.

• Phase II trial tests pembrolizumab combination for MSS metastatic colorectal cancer

  A Phase II study evaluated pembrolizumab combined with capecitabine and bevacizumab in patients with microsatellite stable (MSS) metastatic colorectal cancer who had progressed on prior treatment, assessing safety and preliminary efficacy in this difficult-to-treat population. (Clinical Colorectal Cancer)

• Pilot study tracks circulating tumor DNA to detect minimal residual disease after liver metastasis surgery

  Researchers used personalized ctDNA monitoring in 10 patients with colorectal cancer liver metastases to detect minimal residual disease after resection, moving from tissue sequencing to highly sensitive digital PCR platforms. (Diagnostics)

• Real-world study compares treatment options for elderly patients with refractory metastatic disease

  A retrospective study in Taiwan evaluated trifluridine/tipiracil plus bevacizumab versus regorafenib in elderly patients with refractory metastatic colorectal cancer, providing real-world effectiveness data for this geriatric population. (Cancers)

• Review examines what colonoscopy surveillance does and doesn't prevent in Lynch syndrome

  Researchers reviewed colonoscopic surveillance outcomes in Lynch syndrome, clarifying how regular screening reduces colorectal cancer incidence through polypectomy and mortality through early detection in this hereditary cancer syndrome. (Journal of Medical Genetics)

Research continues to refine detection methods and treatment approaches across different patient populations.

The CRC Digest

Research intelligence for the colorectal cancer community

Content is curated with AI assistance and reviewed by the editorial team.

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