CRISPR Screens Reveal How MSI-H Tumors Depend on WRN Helicase

◇ RESEARCH

Genome-wide CRISPR screens identified SMARCAL1 as a key modulator of WRN dependency in MSI-H colorectal cancer, with loss of SMARCAL1 rendering cells resistant to the WRN inhibitor HRO761. The findings shed light on mechanisms governing sensitivity to WRN-targeted therapies in microsatellite-unstable tumors. (Cancer Research)