Preclinical research identifies dihydroorotate dehydrogenase (DHODH) as a selective metabolic dependency in PIK3CA-mutant CRC; DHODH inhibition reduces cancer cell self-renewal and tumor initiation by disrupting PI3K-AKT signaling. (Cell Reports)
DHODH Identified as Metabolic Vulnerability in PIK3CA-Mutant Colorectal Cancer
The CRC Digest