Early-Onset CRC Shows Distinct Mutation Profile in Meta-Analysis of 154,982 Patients

◇ RESEARCH

A systematic review found that colorectal cancer diagnosed before age 50 has higher frequencies of TP53 and SMAD4 mutations and lower frequencies of APC, KRAS, and BRAF mutations compared to late-onset disease, suggesting different mechanisms of cancer development in younger adults. (Cancers)