Genomic Analysis Reveals Distinct Mutation Patterns in Early-Onset vs. Average-Onset Metastatic CRC

◇ RESEARCH

A real-world next-generation sequencing study of 1,892 metastatic CRC patients found genomic differences between 376 early-onset cases (diagnosed before age 50) and 1,516 average-onset cases, potentially informing personalized treatment strategies. (JCO Precis Oncol)