Researchers found that the somatic mutations KRAS-G12C and PIK3CA-Q546K are highly enriched in MUTYH-associated polyposis tumors and rarely seen in sporadic cases, making them useful for reclassifying uncertain MUTYH variants. (Human Mutation)
KRAS-G12C and PIK3CA hotspot mutations help reclassify MUTYH variants
The CRC Digest