Large cohort study maps RAS-pathway mutation patterns in 1,243 colorectal cancer samples

◇ RESEARCH

Whole-exome sequencing revealed KRAS mutations in 35.3% of tumors, BRAF V600E in 6.8%, and PIK3CA in 17.8%, with KRAS-PIK3CA co-mutations occurring in 10.1% overall; RAS-mutant tumors were enriched in right-sided and microsatellite-stable disease. (Cancer Medicine)