Meta-analysis shows ctDNA after surgery strongly predicts recurrence risk

◇ RESEARCH

A meta-analysis of seven prospective cohorts found that postoperative circulating tumor DNA positivity was associated with increased recurrence risk (pooled hazard ratio, 7.60; 95% CI, 4.70-12.31) after curative-intent colorectal cancer resection, though the review notes that prognostic validity alone does not establish treatment-decision utility. (J Gastrointest Cancer)