New gene circuit platform targets multiple KRAS mutations in preclinical models

◇ RESEARCH

Researchers developed a platform that enables in vivo self-assembly of small extracellular vesicles encapsulating KRAS-specific siRNAs for broad targeting of KRAS mutants, showing activity in orthotopic models of KRAS G12D-, G12V-, and G13D-driven colorectal cancer. (Journal of Controlled Release)