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Skip to content The CRC Digest Early-onset CRC rising in Switzerland despite overall decline A nationwide study from 1980–2021 shows colorectal cancer incidence declining in older adults but increasing in those under 50, mirroring global trends. (European Journal of Cancer) This content is informational only and does not constitute

Skip to content The CRC Digest ▸ ETV7 protein drives 5-FU resistance through immune pathway activation Elevated ETV7 expression in CRC promotes resistance to 5-fluorouracil chemotherapy by upregulating CXCL1, which triggers neutrophil extracellular trap formation and enhances tumor cell survival and invasion. (Communications Biology) This content is informational only and does

Skip to content The CRC Digest Study evaluates risk at second surveillance colonoscopy New Hampshire registry data assessed advanced findings at third colonoscopy based on index adenoma characteristics and first surveillance results. (Clinical Gastroenterology and Hepatology) This content is informational only and does not constitute medical advice. Always consult your

Skip to content The CRC Digest Asian screening programs compared across Japan, South Korea, and Taiwan Comprehensive review examines national CRC screening strategies, effectiveness, and quality assurance frameworks in Asia's established programs. (Journal of Gastroenterology and Hepatology) This content is informational only and does not constitute medical advice.

Skip to content The CRC Digest Females face higher chemotherapy toxicity in metastatic disease Large database analysis confirms females experience more severe side effects from standard mCRC regimens despite similar survival benefits. (European Journal of Cancer) This content is informational only and does not constitute medical advice. Always consult your

Skip to content The CRC Digest ▪ Urinary extracellular vesicles show promise for minimal residual disease detection Study of 160 CRC patients compared urinary EVs to plasma ctDNA for liquid biopsy, finding urinary EVs may offer a non-invasive option for monitoring disease after surgery. (Cancer Science) This content is informational only

Skip to content The CRC Digest RECAST trial compares two first-line regimens with ramucirumab for metastatic colorectal cancer — European Journal of Cancer The randomized phase II WJOG9216G (RECAST) study compared FOLFIRI plus ramucirumab versus FOLFOXIRI plus ramucirumab as first-line treatment for metastatic colorectal cancer. The trial examines whether the more

Skip to content The CRC Digest FIERCE study assesses safety of trifluridine/tipiracil with radiation before rectal cancer surgery — Clinical Colorectal Cancer The phase Ib FIERCE study evaluated the safety of neoadjuvant trifluridine/tipiracil with concurrent radiation in resectable stage II/III rectal cancer. This trial explores whether this oral