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ctDNA-Guided Surveillance Doubles Curative Treatment Rate for Recurrent CRC

Skip to content The CRC Digest ◆ TRIAL DATA ctDNA-Guided Surveillance Doubles Curative Treatment Rate for Recurrent CRC In the phase III FIND trial, patients monitored with circulating tumor DNA testing after surgery were twice as likely to receive curative-intent treatment when cancer recurred compared to standard surveillance (48.1% vs

CRC Research Update — August 17, 2026

Today's colorectal cancer research highlights

MLH1-Deficient Lynch Syndrome Case Highlights Management Dilemma

Skip to content The CRC Digest MLH1-Deficient Lynch Syndrome Case Highlights Management Dilemma The co-occurrence of a germline MLH1 pathogenic variant and a GALT/dome carcinoma raises questions about optimal management in the absence of high-risk histologic features. (ACG Case Rep J) This content is informational only and does not

Rare GALT/Dome Carcinoma Found in Woman With Lynch Syndrome

Skip to content The CRC Digest Rare GALT/Dome Carcinoma Found in Woman With Lynch Syndrome A woman in her early 40s with MLH1-deficient Lynch syndrome was incidentally found to have a cecal GALT/dome carcinoma during routine surveillance, raising management questions about prophylactic colectomy versus endoscopic surveillance. (ACG Case

Referral Center Reports Characteristics of Early-Onset CRC Patients

Skip to content The CRC Digest Referral Center Reports Characteristics of Early-Onset CRC Patients A retrospective cohort study of 56 patients under age 50 with colorectal cancer (median age 42 years) found the most frequent tumor location was the right colon. (Acta Gastroenterol Latinoam) This content is informational only and

Prediagnostic Weight Loss May Explain the "Obesity Paradox" in CRC Survival

Skip to content The CRC Digest ♥ LIVING WITH CRC Prediagnostic Weight Loss May Explain the "Obesity Paradox" in CRC Survival A multicenter study of colorectal cancer patients found that cancer-associated weight loss before diagnosis may account for the apparent survival advantage seen in patients with elevated BMI at

New Computational Model Predicts Drug Combinations That Account for Microbiome Effects

Skip to content The CRC Digest ◇ RESEARCH New Computational Model Predicts Drug Combinations That Account for Microbiome Effects Researchers developed a microbiome-aware framework combining machine learning and metabolic models to predict synergistic drug combinations for colorectal cancer in the presence of Fusobacterium nucleatum and other microbes. (Cell Rep Methods) This

Resourcefulness May Buffer Stress and Improve Quality of Life for Ostomy Patients

Skip to content The CRC Digest ♥ LIVING WITH CRC Resourcefulness May Buffer Stress and Improve Quality of Life for Ostomy Patients A cross-sectional study of 464 colorectal cancer patients with intestinal ostomy found that resourcefulness mediated the relationship between perceived stress and quality of life, suggesting a potential target for

Updated ACS Guideline Addresses Blood Tests for Colorectal Cancer Screening

Skip to content The CRC Digest ▪ SCREENING Updated ACS Guideline Addresses Blood Tests for Colorectal Cancer Screening A JAMA article by Rubin discusses what an updated ACS guideline says about blood-based screening tests for colorectal cancer. (JAMA) This content is informational only and does not constitute medical advice. Always consult

CRC Research Update — August 16, 2026

Today's colorectal cancer research highlights