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BREAKWATER trial compares encorafenib, cetuximab, and FOLFIRI versus FOLFIRI with or without bevacizumab in BRAF V600E-mutant colorectal cancer

Skip to content The CRC Digest ◆ TRIAL DATA BREAKWATER trial compares encorafenib, cetuximab, and FOLFIRI versus FOLFIRI with or without bevacizumab in BRAF V600E-mutant colorectal cancer This randomized study evaluated targeted therapy combinations specifically for patients with BRAF V600E mutations, a subtype associated with poorer outcomes. (Annals of Oncology) This

CRC Research Update — July 18, 2026

Today's colorectal cancer research highlights

Study reveals sex-specific metabolic comorbidity patterns in CRC patients

Skip to content The CRC Digest Study reveals sex-specific metabolic comorbidity patterns in CRC patients Researchers explored sex-specific prevalence and co-occurrence of Type 2 Diabetes Mellitus and Non-Alcoholic Fatty Liver Disease among CRC patients using electronic medical records. (Front Med) This content is informational only and does not constitute medical

Baseline ctDNA analyzed for thrombotic risk in locally advanced rectal cancer

Skip to content The CRC Digest Baseline ctDNA analyzed for thrombotic risk in locally advanced rectal cancer Plasma ctDNA was analyzed by droplet digital PCR for tumor-specific mutations including KRAS, NRAS, BRAF, and PIK3CA to explore association with VTE occurrence. (Cancer Treat Res Commun) This content is informational only and

Salivary microbiome evaluated as non-invasive screening tool for early-onset CRC

Skip to content The CRC Digest Salivary microbiome evaluated as non-invasive screening tool for early-onset CRC High-throughput 16S ribosomal RNA gene sequencing of saliva samples showed distinct microbiota profiles in EOCRC patients compared to controls. (BMC Microbiol) This content is informational only and does not constitute medical advice. Always consult

Study examines colonoscopy impact in older adults with borderline FIT values

Skip to content The CRC Digest Study examines colonoscopy impact in older adults with borderline FIT values Researchers used a regression discontinuity design to investigate whether CRC screening affects incidence among 2,773 adults aged 71-75 with FIT values between 80-120 ng/ml. (Int J Epidemiol) This content is informational

Salivary microbiome profiles distinguish early-onset CRC patients from healthy controls

Skip to content The CRC Digest Salivary microbiome profiles distinguish early-onset CRC patients from healthy controls Researchers collected saliva samples from 65 EOCRC patients and 63 controls, profiling the microbiota and developing screening models using machine learning algorithms. (BMC Microbiol) This content is informational only and does not constitute medical

CRC Research Finding

Skip to content The CRC Digest ♥ Dietary guidance during treatment linked to quality of life after cancer care A cross-sectional study of 610 cancer survivors (including 132 colorectal cancer patients) examined whether guidance on dietary habits or nutrition-related problems from healthcare professionals during treatment was associated with quality of life

Alabama study examines lifestyle and metabolic factors in early- vs late-onset CRC

Skip to content The CRC Digest Alabama study examines lifestyle and metabolic factors in early- vs late-onset CRC A retrospective study from 2010–2023 investigated whether associations between lifestyle factors (smoking, BMI) and clinical factors (type 2 diabetes, hypertension, hyperlipidemia) and age at CRC diagnosis differed by race. (Cancer Causes

Meta-analysis projects rising early-onset CRC burden through 2030

Skip to content The CRC Digest Meta-analysis projects rising early-onset CRC burden through 2030 A systematic review and meta-analysis evaluated early-onset colorectal cancer (diagnosed under age 50) incidence and temporal trends from 1990 to 2021, identifying associated risk factors and projecting burden through 2030. (Cureus) This content is informational only