LIVING WITH CRC
Pre-chemotherapy anxiety and sleep disturbance linked to immune changes and quality of lifeA prospective study of 268 CRC patients assessed within 24 hours before their first chemotherapy cycle found that anxiety-sleep disturbance symptoms were associated with neuroendocrine dysregulation, cellular immune alterations, and quality of life, with cortisol and IL-6 acting as biological mediators. (Neuroimmunomodulation)