Propionate enhances CD8+ T-cell infiltration and immunotherapy response in preclinical models

◇ RESEARCH

A study using syngeneic MSI-H and MSS murine colorectal cancer models found that propionate, a short-chain fatty acid produced by gut microbiota, promoted CD8+ T-cell infiltration and enhanced efficacy when combined with anti-PD-L1 blockade. (J Immunother Cancer)