Single-cell study identifies ETV4-MC1R pathway driving immunotherapy resistance in MSI-H CRC

◇ RESEARCH

Researchers used single-cell RNA sequencing to compare PD-1-resistant and PD-1-sensitive MSI-H metastatic colorectal tumors, identifying a gene regulatory network involving ETV4 and MC1R that may explain why some MSI-H cancers don't respond to immunotherapy. (Int J Surg)