SPP1+ macrophages linked to chemotherapy resistance in colorectal liver metastasis

◇ RESEARCH

Single-cell RNA sequencing identified a macrophage subpopulation marked by elevated SPP1 expression that is significantly enriched in patients who respond insufficiently to neoadjuvant chemotherapy; these cells suppress CD8+ T cell function through the SPP1-CD44 signaling pathway. (Molecular Biomedicine)