Analysis of 217 patients with dMMR/MSI-H colorectal cancer found that stage III/IV tumors had reduced immune infiltration and upregulated epithelial IDO1 expression compared to stage I/II, suggesting immune evasion mechanisms in locally advanced disease. (Oncoimmunology)
Stage III/IV MSI-H CRC Shows Reduced T-Cell Infiltration and Elevated IDO1
The CRC Digest