Study Identifies Risk Factors for Serious Intestinal Side Effect With CAPOX Chemotherapy Skip to content The CRC Digest ♥ LIVING WITH CRC Study Identifies Risk Factors for Serious Intestinal Side Effect With CAPOX Chemotherapy Researchers examined the incidence and risk factors of non-neutropenic enterocolitis—a serious intestinal inflammation—in colorectal cancer patients receiving adjuvant capecitabine and oxaliplatin (CAPOX) chemotherapy. (Clinical Colorectal Cancer) This
ctDNA-Guided Surveillance Doubles Curative Treatment Rate for Recurrent CRC Skip to content The CRC Digest ◆ TRIAL DATA ctDNA-Guided Surveillance Doubles Curative Treatment Rate for Recurrent CRC In the phase III FIND trial, patients monitored with circulating tumor DNA testing after surgery were twice as likely to receive curative-intent treatment when cancer recurred compared to standard surveillance (48.1% vs
Adjuvant chemotherapy benefits occur early, not in late recurrences Skip to content The CRC Digest ◆ TRIAL DATA Adjuvant chemotherapy benefits occur early, not in late recurrences A systematic review of phase III randomized controlled trials for gastrointestinal malignancies including colorectal cancer found that recurrence-free survival improvements were driven by early divergences during active chemotherapy, while late recurrences were not
Phase III trial launches to prevent oxaliplatin-induced neuropathy in adjuvant treatment Skip to content The CRC Digest ♥ LIVING WITH CRC Phase III trial launches to prevent oxaliplatin-induced neuropathy in adjuvant treatment The PROSPER trial will test lecithinized superoxide dismutase (PC-SOD) against placebo to prevent chemotherapy-induced peripheral neuropathy in stage II/III colorectal cancer patients receiving adjuvant mFOLFOX6, following promising phase II