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A collection of 632 issues

Ultra-Processed Foods Linked to Accelerated Aging in Colorectal Tissue

Skip to content The CRC Digest ◇ RESEARCH Ultra-Processed Foods Linked to Accelerated Aging in Colorectal Tissue A study of 106 participants found that higher intake of ultra-processed foods was significantly associated with accelerated epigenetic aging in normal colorectal tissues, a finding that may help explain rising early-onset CRC rates. (JNCI

Meta-Analysis Links Metabolic Liver Disease to Early-Onset Advanced Colorectal Neoplasia

Skip to content The CRC Digest ◇ RESEARCH Meta-Analysis Links Metabolic Liver Disease to Early-Onset Advanced Colorectal Neoplasia Systematic review and meta-analysis of cohort studies quantified the association between metabolic dysfunction-associated steatotic liver disease and early-onset advanced colorectal neoplasia, informing risk stratification. (J Gastrointest Oncol) This content is informational only and

Chinese Expert Consensus Establishes Evaluation Standards for AI in Colorectal Cancer

Skip to content The CRC Digest ● REGULATORY Chinese Expert Consensus Establishes Evaluation Standards for AI in Colorectal Cancer (Zhonghua Wei Chang Wai Ke Za Zhi) This content is informational only and does not constitute medical advice. Always consult your oncologist or care team. © 2026 The CRC Digest — crcdigest.com

Single-Institution Experience with Cytoreductive Surgery and HIPEC for Colorectal Peritoneal Metastases

Skip to content The CRC Digest ▸ TREATMENT Single-Institution Experience with Cytoreductive Surgery and HIPEC for Colorectal Peritoneal Metastases Retrospective study (2009–2024) evaluated cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy in patients with colorectal peritoneal metastases. (Radiol Oncol) This content is informational only and does not constitute medical advice. Always

Machine Learning Model Combines FIT with Clinical Data to Triage Fast-Track Colonoscopy Referrals

Skip to content The CRC Digest ▪ SCREENING Machine Learning Model Combines FIT with Clinical Data to Triage Fast-Track Colonoscopy Referrals Swedish researchers developed and externally validated risk models combining faecal immunochemical test results with age, sex, symptoms, and imaging to prioritize 2,539 fast-track colonoscopies, aiming to improve endoscopy capacity.

Three Distinct Activity Profiles Identified in CRC Survivors Shortly After Treatment

Skip to content The CRC Digest ◇ RESEARCH Three Distinct Activity Profiles Identified in CRC Survivors Shortly After Treatment Accelerometer data from 358 colorectal cancer patients revealed three activity profiles: most sedentary (16%), average (53%), and highly active (31%). (J Cancer Surviv) This content is informational only and does not constitute

Fruquintinib plus immunotherapy evaluated in MSS refractory mCRC

Skip to content The CRC Digest Fruquintinib plus immunotherapy evaluated in MSS refractory mCRC A retrospective study of 145 patients with microsatellite-stable metastatic CRC who had progressed after at least two systemic treatment lines aimed to evaluate whether fruquintinib alone, fruquintinib plus a PD-1 inhibitor, or the combination with radiotherapy

Hospitalization outcomes differ between early- and late-onset CRC patients

Skip to content The CRC Digest Hospitalization outcomes differ between early- and late-onset CRC patients A national database study (2016-2020) compared hospitalization trends and outcomes in patients diagnosed before age 50 versus those 50 and older, finding distinct patterns in mortality, length of stay, and associations with obesity and sociodemographic

Dietary and metabolic risk factors drive rising early-onset CRC rates in the U.S.

Skip to content The CRC Digest ♥ LIVING WITH CRC Dietary and metabolic risk factors drive rising early-onset CRC rates in the U.S. A 33-year analysis of Global Burden of Disease data shows that while traditional colorectal cancer rates in older adults have declined, early-onset cases (diagnosed under age 50)

Meta-analysis finds conflicting evidence on ctDNA RAS testing for anti-EGFR therapy

Skip to content The CRC Digest ◇ RESEARCH Meta-analysis finds conflicting evidence on ctDNA RAS testing for anti-EGFR therapy A systematic review of patients with tissue RAS wild-type tumors receiving first-line chemotherapy plus anti-EGFR therapy found inconsistent results on whether ctDNA RAS status predicts outcomes, possibly due to differences in assay