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A collection of 624 issues

Review examines why microsatellite-stable tumors resist immunotherapy

Skip to content The CRC Digest ◇ RESEARCH Review examines why microsatellite-stable tumors resist immunotherapy A systematic review found that mismatch repair-proficient, microsatellite stable tumors remain resistant to immunotherapy due to low neoantigen load, defects in antigen presentation, and Wnt/β-catenin pathway activity that reduce immune recognition and T-cell infiltration. (Molecules)

AI algorithm stratifies stage II/IIIA colorectal cancer recurrence risk from standard pathology slides

Skip to content The CRC Digest ◇ RESEARCH AI algorithm stratifies stage II/IIIA colorectal cancer recurrence risk from standard pathology slides HistoNav, a deep-learning algorithm analyzing H&E-stained tissue samples from 2,095 patients, identified low-, intermediate-, and high-risk groups with 5-year disease-specific survival rates of 93.2%, 84.

AI-assisted colonoscopy systems standardize polyp detection accuracy

Skip to content The CRC Digest ▪ SCREENING AI-assisted colonoscopy systems standardize polyp detection accuracy Computer-aided detection and diagnosis systems using deep learning convolutional neural networks reduce inter-operator variability in adenoma detection rates and help identify diminutive and morphologically subtle lesions. (Journal of Clinical Medicine) This content is informational only and

FIT-based screening linked to earlier colorectal cancer detection in Romania

Skip to content The CRC Digest ▪ SCREENING FIT-based screening linked to earlier colorectal cancer detection in Romania A retrospective study of 236 patients found that population-based screening using the fecal immunochemical test detected colorectal cancer at earlier stages compared to symptom-driven colonoscopy. (Cancers) This content is informational only and does

Early-onset and average-onset metastatic colorectal cancer share similar genomic landscapes

Skip to content The CRC Digest ◇ RESEARCH Early-onset and average-onset metastatic colorectal cancer share similar genomic landscapes An analysis of 1,892 patients found that major driver alterations. TP53, APC, and KRAS — occurred at comparable frequencies in metastatic colorectal cancer diagnosed before age 50 versus later, suggesting the diseases are

Pooled Analysis Examines Prognostic Value of KRAS Mutations and Liver Metastases

Skip to content The CRC Digest Pooled Analysis Examines Prognostic Value of KRAS Mutations and Liver Metastases A pooled analysis of third-line placebo-controlled trials from the ARCAD CRC Database evaluated the prognostic impact of liver metastases and KRAS mutations in metastatic colorectal cancer patients. (Clinical Colorectal Cancer) This content is

Scoping Review Maps Global Variation in Early-Onset CRC Patterns

Skip to content The CRC Digest Scoping Review Maps Global Variation in Early-Onset CRC Patterns A scoping review of studies published 2019–2024 synthesized contemporary evidence on epidemiologic, molecular, and survival differences in early-onset colorectal cancer across regions and racial/ethnic groups. (Journal of Gastrointestinal Cancer) This content is informational

Peer-Led Campus Program Targets CRC Awareness Among Young Adults

Skip to content The CRC Digest Peer-Led Campus Program Targets CRC Awareness Among Young Adults GRACCE, a community-led ambassador-driven education program, recruited student ambassadors from five universities to deliver campus-based CRC education, addressing rising incidence among young adults. (Journal of Cancer Education) This content is informational only and does not

Vietnamese CRC Survivors Report Significant Unmet Supportive Care Needs

Skip to content The CRC Digest ♥ LIVING WITH CRC Vietnamese CRC Survivors Report Significant Unmet Supportive Care Needs A cross-sectional study of 354 colorectal cancer survivors in Vietnam identified unmet supportive care needs following primary treatment, highlighting gaps in the healthcare system and cultural context. (European Journal of Oncology Nursing)

Seven-Year Study Maps Dysplasia Patterns in Sessile Serrated Lesions

Skip to content The CRC Digest ▪ SCREENING Seven-Year Study Maps Dysplasia Patterns in Sessile Serrated Lesions A retrospective analysis of all sessile serrated lesions from a single high-detection-rate endoscopist in Australia assessed the prevalence and anatomical distribution of dysplasia, a critical stage in progression to colorectal cancer. (Gastroenterology and Hepatology