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Skip to content The CRC Digest ◆ TRIAL DATA Real-world study identifies factors predicting immunotherapy response in MSI-H/dMMR gastrointestinal cancers — ESMO Real World Data and Digital Oncology A multicenter retrospective study of 122 patients with advanced MSI-H/dMMR (microsatellite instability-high/mismatch repair deficiency) gastrointestinal tumors treated with immune checkpoint inhibitors

Skip to content The CRC Digest ◆ TRIAL DATA Circulating tumor DNA testing after surgery predicts recurrence in stage III colon cancer — Journal of Clinical Oncology Analysis from the phase III Alliance N0147 trial evaluated a tissue-free circulating tumor DNA (ctDNA) assay in patients receiving FOLFOX-based adjuvant chemotherapy after surgery for

Skip to content The CRC Digest ▪ SCREENING Blood-based circulating tumor DNA shows promise for early colorectal cancer detection — Digestive Diseases A systematic review and meta-analysis evaluated the accuracy of blood-based circulating tumor DNA (ctDNA) tests for detecting colorectal cancer in people without symptoms. These tests look for tiny fragments of

Skip to content The CRC Digest ◆ TRIAL DATA Neoadjuvant chemotherapy alone may be as effective as chemoradiation for some rectal cancers — Journal of Clinical Oncology The phase III CONVERT trial compared neoadjuvant chemotherapy (CAPOX — capecitabine plus oxaliplatin) with traditional chemoradiation for locally advanced rectal cancer patients whose tumors haven'

Skip to content The CRC Digest ◆ TRIAL DATA Aflibercept plus 5-FU shows promise for frail elderly patients with metastatic colorectal cancer — European Journal of Cancer The phase II ELDERLY trial compared two first-line treatment options for older adults (age 70+) or frail patients with metastatic colorectal cancer who aren'

Skip to content The CRC Digest Cancer Mortality Projections Through 2026 for Young Adults Across 15 Countries Study projects early-onset cancer mortality trends through 2026 for ages 25-49 across 15 high-income countries, with special focus on colorectal cancer patterns. (Cancer Causes & Control) This content is informational only and does

Skip to content The CRC Digest Prognostic Factors Identified for Young Adults with Liver Metastases Analysis of 3,188 young adults aged 18-45 with stage IV colorectal cancer and liver metastases identified key prognostic factors affecting overall survival. (Discovery Oncology) This content is informational only and does not constitute medical

Skip to content The CRC Digest ♥ Causes of Death Shifting in Colon and Rectal Cancer Patients Over Two Decades SEER database analysis reveals temporal trends in what causes death among colorectal cancer patients, reflecting changes in treatment approaches, screening age guidelines, and new health threats like COVID-19 over the past

Skip to content The CRC Digest Fecal hemoglobin levels may guide post-polypectomy surveillance timing A study of 4 million FIT-based screening participants explored using fecal hemoglobin measurements to personalize surveillance intervals after polyp removal. (Gastroenterology) This content is informational only and does not constitute medical advice. Always consult your oncologist

Skip to content The CRC Digest Network analysis identifies most effective screening interventions A systematic review and network meta-analysis compared different interventions for increasing colorectal cancer screening uptake. (Gastroenterology) This content is informational only and does not constitute medical advice. Always consult your oncologist or care team. © 2026 The CRC