Prolonged Response to Pembrolizumab in BRAF V600E MSS Colorectal Cancer Skip to content The CRC Digest Prolonged Response to Pembrolizumab in BRAF V600E MSS Colorectal Cancer A patient with BRAF V600E-mutant microsatellite-stable metastatic colorectal cancer achieved a prolonged response to pembrolizumab following a dynamic increase in tumor mutational burden. (The Oncologist) This content is informational only and does not constitute