Furin Inhibition Targets KRAS and BRAF Pathways Skip to content The CRC Digest Furin Inhibition Targets KRAS and BRAF Pathways Blocking Furin improved chemotherapy sensitivity in KRAS- and BRAF-mutant organoids. (Oncogene) This content is informational only and does not constitute medical advice. Always consult your oncologist or care team. © 2026 The CRC Digest — crcdigest.com
CRC Research Finding Skip to content The CRC Digest ◇ Furin Protein Sustains Tumor Signals in KRAS- and BRAF-Mutated Colorectal Cancer Preclinical research identifies Furin as a key mediator of the TGF-β1-COX-2 pathway in KRAS- and BRAF-mutant colorectal cancer; blocking Furin suppressed tumor growth and enhanced sensitivity to chemotherapy in organoid models. (Oncogene) This
Encorafenib and cetuximab re-challenge combined with nivolumab in BRAF-mutated colorectal cancer Skip to content The CRC Digest ▸ TREATMENT Encorafenib and cetuximab re-challenge combined with nivolumab in BRAF-mutated colorectal cancer — Clinical Colorectal Cancer A case report from the AGMT mCRC Registry documented successful encorafenib and cetuximab re-challenge combined with nivolumab in BRAF V600E mutated, mismatch-repair-proficient metastatic colorectal cancer. If you have BRAF
KRAS, NRAS, and BRAF mutation patterns in Chile Skip to content The CRC Digest KRAS, NRAS, and BRAF mutation patterns in Chile Real-world data from 999 Chilean patients characterized the frequency and sex-specific distribution of KRAS, NRAS, and BRAF mutations. (Journal of Gastrointestinal Oncology) This content is informational only and does not constitute medical advice. Always consult your
RAS and BRAF status in MSI-H/dMMR metastatic CRC Skip to content The CRC Digest RAS and BRAF status in MSI-H/dMMR metastatic CRC New guidance on the role of RAS and BRAF mutations in MSI-high and dMMR metastatic colorectal cancer. (Oncodaily) This content is informational only and does not constitute medical advice. Always consult your oncologist or care