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crc-research

A collection of 723 issues

Systematic review evaluates treatments for bowel dysfunction after colorectal cancer surgery

Skip to content The CRC Digest ♥ LIVING WITH CRC Systematic review evaluates treatments for bowel dysfunction after colorectal cancer surgery Eight studies examined pharmacological therapies including serotonin receptor antagonists, herbal medicines, diazepam, and Botulinum A toxin for managing bowel dysfunction following sphincter-preserving surgeries. (Adv Pharm Bull) This content is informational

Meta-analysis examines timing of chemotherapy after colorectal cancer surgery

Skip to content The CRC Digest ◆ TRIAL DATA Meta-analysis examines timing of chemotherapy after colorectal cancer surgery A systematic review and meta-analysis evaluated the impact of early versus delayed postoperative chemotherapy on overall survival in colorectal cancer patients, aiming to guide clinical decisions on optimal chemotherapy timing. (J Gastrointest Cancer)

HER2-mutated colorectal cancers show distinct genomic features from HER2-amplified tumors

Skip to content The CRC Digest ◇ RESEARCH HER2-mutated colorectal cancers show distinct genomic features from HER2-amplified tumors Analysis of 4,348 CRC patients found that ERBB2/HER2 mutations occurred in 2.2% and amplifications in 2.0%, with distinct genomic landscapes and clinical characteristics between the two groups. (Oncologist) This

Consensus Molecular Subtype Classification Feasible Using Preoperative Biopsies

Skip to content The CRC Digest Consensus Molecular Subtype Classification Feasible Using Preoperative Biopsies A prospective pilot study evaluated the feasibility of consensus molecular subtype classification of colorectal cancer using preoperative biopsy specimens, examining RNA yield, quality, and concordance between different biopsy forceps. (Journal of the Anus, Rectum and Colon)

Unexplained Microcytosis in 40-Year-Old: Missed Opportunity for Early Diagnosis

Skip to content The CRC Digest Unexplained Microcytosis in 40-Year-Old: Missed Opportunity for Early Diagnosis A case report highlights how isolated microcytosis and iron deficiency in a 40-year-old male with morbid obesity was a missed early indicator of colorectal cancer. (South Dakota Medicine) This content is informational only and does

Medicaid Expansion Linked to Lower Mortality in Metastatic CRC

Skip to content The CRC Digest ♥ LIVING WITH CRC Medicaid Expansion Linked to Lower Mortality in Metastatic CRC A SEER database analysis found that Medicaid expansion was associated with decreased mortality in patients younger than 65 diagnosed with colorectal cancer and synchronous liver metastasis. (Annals of Surgery) This content is

First Patient Dosed in Phase 2 Trial of Oral KRAS G12D Inhibitor

Skip to content The CRC Digest ▸ TREATMENT First Patient Dosed in Phase 2 Trial of Oral KRAS G12D Inhibitor Verastem Oncology has dosed the first patient in a phase 2 registration-directed trial of VS-7375, an oral KRAS G12D inhibitor, for KRAS G12D-mutated metastatic colorectal cancer. (BioSpace) This content is informational

Liquid Biopsy Guides HER2 Therapy Rechallenge in Metastatic CRC

Skip to content The CRC Digest ▸ TREATMENT Liquid Biopsy Guides HER2 Therapy Rechallenge in Metastatic CRC A study found that liquid biopsy can guide rechallenge with anti-HER2 therapy in patients with HER2-amplified metastatic colorectal cancer. (JCO Precision Oncology) This content is informational only and does not constitute medical advice. Always

Dynamic ctDNA Methylation Monitoring Guides Postoperative Surveillance in FIND Trial

Skip to content The CRC Digest ◆ TRIAL DATA Dynamic ctDNA Methylation Monitoring Guides Postoperative Surveillance in FIND Trial A prospective, randomized phase III trial tested whether circulating tumor DNA methylation monitoring can guide postoperative surveillance in nonmetastatic colorectal cancer patients. (Journal of Clinical Oncology) This content is informational only and

CRC Research Update — July 31, 2026

Today's colorectal cancer research highlights