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crc-research

A collection of 699 issues

National Database Analysis Examines Post-Pandemic Cancer Screening Patterns

Skip to content The CRC Digest ▪ SCREENING National Database Analysis Examines Post-Pandemic Cancer Screening Patterns Researchers analyzed National Cancer Database records from 2010 to 2023 to compare predicted versus observed incidence rates and late-stage disease proportions for screenable cancers including colorectal cancer following the COVID-19 pandemic screening decline. (Journal of

Cost-Effectiveness Analysis Compares Immunotherapy Options for MSI-H/dMMR mCRC

Skip to content The CRC Digest ▸ TREATMENT Cost-Effectiveness Analysis Compares Immunotherapy Options for MSI-H/dMMR mCRC A U.S. healthcare payer analysis evaluated nivolumab plus ipilimumab versus pembrolizumab and chemotherapy as first-line treatment for the 4-5% of metastatic colorectal cancers that are microsatellite instability-high or mismatch repair deficient. (Advances in

KRAS Mutations Shape Immunosuppressive Tumor Environment

Skip to content The CRC Digest ◇ RESEARCH KRAS Mutations Shape Immunosuppressive Tumor Environment A review describes how KRAS mutations—present in approximately 52% of colorectal cancers—actively create an immunosuppressive tumor microenvironment, presenting a major barrier to both targeted therapy and immunotherapy. (Frontiers in Oncology) This content is informational only

Ultra-Processed Foods Linked to Accelerated Aging in Colorectal Tissue

Skip to content The CRC Digest ◇ RESEARCH Ultra-Processed Foods Linked to Accelerated Aging in Colorectal Tissue A study of 106 participants found that higher intake of ultra-processed foods was significantly associated with accelerated epigenetic aging in normal colorectal tissues, a finding that may help explain rising early-onset CRC rates. (JNCI

CRC Research Update — September 08, 2026

Today's colorectal cancer research highlights

Meta-Analysis Links Metabolic Liver Disease to Early-Onset Advanced Colorectal Neoplasia

Skip to content The CRC Digest ◇ RESEARCH Meta-Analysis Links Metabolic Liver Disease to Early-Onset Advanced Colorectal Neoplasia Systematic review and meta-analysis of cohort studies quantified the association between metabolic dysfunction-associated steatotic liver disease and early-onset advanced colorectal neoplasia, informing risk stratification. (J Gastrointest Oncol) This content is informational only and

Chinese Expert Consensus Establishes Evaluation Standards for AI in Colorectal Cancer

Skip to content The CRC Digest ● REGULATORY Chinese Expert Consensus Establishes Evaluation Standards for AI in Colorectal Cancer (Zhonghua Wei Chang Wai Ke Za Zhi) This content is informational only and does not constitute medical advice. Always consult your oncologist or care team. © 2026 The CRC Digest — crcdigest.com

Single-Institution Experience with Cytoreductive Surgery and HIPEC for Colorectal Peritoneal Metastases

Skip to content The CRC Digest ▸ TREATMENT Single-Institution Experience with Cytoreductive Surgery and HIPEC for Colorectal Peritoneal Metastases Retrospective study (2009–2024) evaluated cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy in patients with colorectal peritoneal metastases. (Radiol Oncol) This content is informational only and does not constitute medical advice. Always

Machine Learning Model Combines FIT with Clinical Data to Triage Fast-Track Colonoscopy Referrals

Skip to content The CRC Digest ▪ SCREENING Machine Learning Model Combines FIT with Clinical Data to Triage Fast-Track Colonoscopy Referrals Swedish researchers developed and externally validated risk models combining faecal immunochemical test results with age, sex, symptoms, and imaging to prioritize 2,539 fast-track colonoscopies, aiming to improve endoscopy capacity.

Three Distinct Activity Profiles Identified in CRC Survivors Shortly After Treatment

Skip to content The CRC Digest ◇ RESEARCH Three Distinct Activity Profiles Identified in CRC Survivors Shortly After Treatment Accelerometer data from 358 colorectal cancer patients revealed three activity profiles: most sedentary (16%), average (53%), and highly active (31%). (J Cancer Surviv) This content is informational only and does not constitute