ATOMIC trial shows 86% three-year disease-free survival with atezolizumab combination Skip to content The CRC Digest ◆ TRIAL DATA ATOMIC trial shows 86% three-year disease-free survival with atezolizumab combination At a median follow-up of 40.9 months in the ATOMIC trial, the 3-year disease-free survival rate was 86.3% in patients receiving atezolizumab plus mFOLFOX6 compared with 76.2% in those
FDA approves atezolizumab plus chemotherapy for Stage III dMMR colon cancer Skip to content The CRC Digest ● REGULATORY FDA approves atezolizumab plus chemotherapy for Stage III dMMR colon cancer The FDA approved atezolizumab in combination with a fluoropyrimidine and oxaliplatin for adjuvant treatment of adult and pediatric patients two years and older with Stage III mismatch repair deficient colon cancer. Efficacy
Chinese herbal formulation may shift pMMR tumors toward dMMR-like phenotype Skip to content The CRC Digest ◇ RESEARCH Chinese herbal formulation may shift pMMR tumors toward dMMR-like phenotype Preclinical research using mouse models found that Xian-Lian-Jie-Du decoction (XLJDD) may modulate proficient mismatch repair (pMMR) colorectal tumors toward a dMMR-like phenotype, potentially enhancing responsiveness to anti-PD-1 therapy. (Phytomedicine) This content is informational
MSI-H/dMMR prevalence varies by age and sex in Japanese cancer cohort Skip to content The CRC Digest ◇ RESEARCH MSI-H/dMMR prevalence varies by age and sex in Japanese cancer cohort Study of 1,130 older patients (median age 78) with gastric, colorectal, and endometrial cancers characterized deficient mismatch repair protein expression patterns, informing immunotherapy eligibility in aging populations. (Jpn J Clin