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dmmr

A collection of 120 issues

Immunotherapy Combination Achieves Complete Response and Polyp Regression in dMMR Colorectal Cancer

Skip to content The CRC Digest Immunotherapy Combination Achieves Complete Response and Polyp Regression in dMMR Colorectal Cancer Case report from the NOUS-209-01 trial describes a patient with mismatch repair-deficient colorectal cancer who achieved complete pathologic response and significant colonic polyp regression following treatment with Nous-209 plus pembrolizumab. (Journal of

CRC Research Update — August 28, 2026

Today's colorectal cancer research highlights

Lynch Syndrome Screening Performance Assessed in Early-Onset CRC Cohort

Skip to content The CRC Digest ◇ RESEARCH Lynch Syndrome Screening Performance Assessed in Early-Onset CRC Cohort The Padua study specifically evaluated mismatch repair testing and Lynch syndrome detection in early-onset CRC patients as part of a universal screening approach. (Cancers) This content is informational only and does not constitute medical

Universal Tumor Screening Evaluated for Lynch Syndrome Detection in 1,022 Consecutive CRC Cases

Skip to content The CRC Digest ▪ SCREENING Universal Tumor Screening Evaluated for Lynch Syndrome Detection in 1,022 Consecutive CRC Cases A University Hospital of Padua study assessed mismatch repair deficiency distribution and Lynch syndrome detection rates across clinical subgroups using immunohistochemistry-based universal tumor screening in consecutive surgical patients. (Cancers)

MD Anderson explains DNA mismatch repair status for patients

Skip to content The CRC Digest MD Anderson explains DNA mismatch repair status for patients An educational resource from MD Anderson helps patients understand mismatch repair deficiency and proficiency, key biomarkers that guide immunotherapy decisions. (UT MD Anderson Cancer Center) This content is informational only and does not constitute medical

Case series documents bowel stenosis following immunotherapy in dMMR colorectal cancer

Skip to content The CRC Digest ♥ LIVING WITH CRC Case series documents bowel stenosis following immunotherapy in dMMR colorectal cancer A case series documents bowel stenosis following immunotherapy in patients with mismatch repair deficient colorectal cancer. (Clinical Colorectal Cancer) This content is informational only and does not constitute medical advice.

Dual immunotherapy shows promise in mismatch repair proficient colon cancer

Skip to content The CRC Digest ◆ TRIAL DATA Dual immunotherapy shows promise in mismatch repair proficient colon cancer The phase 2 NEST trial tested neoadjuvant botensilimab plus balstilimab in patients with resectable colon cancer. The study examined safety, feasibility, and pathologic response before surgical resection. (Clinical Cancer Research) This content

CRC Research Update — August 26, 2026

Today's colorectal cancer research highlights

Case report: POLE mutation combined with dMMR/MSI

Skip to content The CRC Digest ▸ TREATMENT Case report: POLE mutation combined with dMMR/MSI (Am J Ther) This content is informational only and does not constitute medical advice. Always consult your oncologist or care team. © 2026 The CRC Digest — crcdigest.com

Case report: POLE-mutated, dMMR/MSI colorectal cancer

Skip to content The CRC Digest ▸ TREATMENT Case report: POLE-mutated, dMMR/MSI colorectal cancer (Am J Ther) This content is informational only and does not constitute medical advice. Always consult your oncologist or care team. © 2026 The CRC Digest — crcdigest.com