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early-onset

A collection of 112 issues

Calcitriol Modulates Age-Dependent Drug Response in Patient-Derived Colorectal Organoids

Skip to content The CRC Digest Calcitriol Modulates Age-Dependent Drug Response in Patient-Derived Colorectal Organoids Researchers used paired patient-derived normal and tumor colorectal organoids to investigate how calcitriol (the active vitamin D metabolite) modulates chemotherapy response. Dose-response analyses revealed marked interpatient variability, with SN38 being more potent than 5-fluorouracil and

Age-Stratified Mutation Patterns Reveal Distinct Features in Early-Onset CRC

Skip to content The CRC Digest ◇ RESEARCH Age-Stratified Mutation Patterns Reveal Distinct Features in Early-Onset CRC Analysis of 6,762 samples across four age groups found that early-onset colorectal cancer (diagnosed before age 50) shows different mutation patterns compared to later-onset disease, with implications for testing guidelines and therapeutic development.

CRC Research Update — September 04, 2026

Today's colorectal cancer research highlights

Vietnamese Cohort Compares Early- vs Late-Onset CRC Outcomes

Skip to content The CRC Digest Vietnamese Cohort Compares Early- vs Late-Onset CRC Outcomes A retrospective study of 486 patients who underwent curative resection in Vietnam's Mekong Delta compared clinicopathologic features and survival between early-onset and late-onset colorectal cancer. (Arq Bras Cir Dig) This content is informational only

Risk Factors for Early-Onset CRC Reviewed

Skip to content The CRC Digest Risk Factors for Early-Onset CRC Reviewed A clinical review highlights that early-onset CRC (diagnosed before age 50) arises from both nonmodifiable factors (age, family history, race/ethnicity) and modifiable factors (obesity, diet, inactivity, alcohol, tobacco). (Gastrointest Endosc Clin N Am) This content is informational

Early-Onset Colorectal Cancer Incidence Accelerates Through 2023

Skip to content The CRC Digest ▪ SCREENING Early-Onset Colorectal Cancer Incidence Accelerates Through 2023 SEER data show early-onset CRC incidence accelerated during 2019-2023 with an annual percent change of 8.3%, while incidence among adults 65 and older declined. Black patients more often presented with stage IV disease (33.9%

CRC Research Update — September 03, 2026

Today's colorectal cancer research highlights

Screening Age Thresholds Miss Early-Onset CRC Risk Established in Youth

Skip to content The CRC Digest Screening Age Thresholds Miss Early-Onset CRC Risk Established in Youth A new analysis argues that age-based screening creates a "blind spot" for early-onset colorectal cancer because high-risk states may be established through early-life exposures decades before screening begins at age 45. (Frontiers

CRC Research Update — September 02, 2026

Today's colorectal cancer research highlights

Case series from Tanzania documents colorectal cancer in patients under 30

Skip to content The CRC Digest ♥ LIVING WITH CRC Case series from Tanzania documents colorectal cancer in patients under 30 Three patients under age 30 presented with advanced disease after prolonged symptoms including rectal bleeding and weight loss; two had mucinous adenocarcinoma and one had a family history suggesting hereditary