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early-onset

A collection of 127 issues

Early-Onset Colorectal Cancer Incidence Accelerates Through 2023

Skip to content The CRC Digest ▪ SCREENING Early-Onset Colorectal Cancer Incidence Accelerates Through 2023 SEER data show early-onset CRC incidence accelerated during 2019-2023 with an annual percent change of 8.3%, while incidence among adults 65 and older declined. Black patients more often presented with stage IV disease (33.9%

CRC Research Update — September 03, 2026

Today's colorectal cancer research highlights

Screening Age Thresholds Miss Early-Onset CRC Risk Established in Youth

Skip to content The CRC Digest Screening Age Thresholds Miss Early-Onset CRC Risk Established in Youth A new analysis argues that age-based screening creates a "blind spot" for early-onset colorectal cancer because high-risk states may be established through early-life exposures decades before screening begins at age 45. (Frontiers

CRC Research Update — September 02, 2026

Today's colorectal cancer research highlights

Case series from Tanzania documents colorectal cancer in patients under 30

Skip to content The CRC Digest ♥ LIVING WITH CRC Case series from Tanzania documents colorectal cancer in patients under 30 Three patients under age 30 presented with advanced disease after prolonged symptoms including rectal bleeding and weight loss; two had mucinous adenocarcinoma and one had a family history suggesting hereditary

CRC Research Update — August 31, 2026

Today's colorectal cancer research highlights

Roadmap for early-onset colorectal cancer prevention highlights lifestyle factors and emerging risk pathways

Skip to content The CRC Digest Roadmap for early-onset colorectal cancer prevention highlights lifestyle factors and emerging risk pathways Review identifies obesity, metabolic conditions, poor diet, and sedentary behavior as key EOCRC risk factors, with growing evidence for early-life and gut microbial exposures. (Nature Reviews Cancer) This content is informational

CRC Research Update — August 30, 2026

Today's colorectal cancer research highlights

Genomic Differences Between Early-Onset and Average-Onset Metastatic CRC Identified

Skip to content The CRC Digest ◇ RESEARCH Genomic Differences Between Early-Onset and Average-Onset Metastatic CRC Identified A real-world next-generation sequencing study compared the genomic landscape of early-onset colorectal cancer with average-onset metastatic disease, identifying distinct molecular features in younger patients. (JCO Precision Oncology) This content is informational only and does

Age-stratified analysis reveals CEMIP elevation in early-onset CRC

Skip to content The CRC Digest ◇ RESEARCH Age-stratified analysis reveals CEMIP elevation in early-onset CRC Transcriptomic profiling identified CEMIP, NKD2, and FOXQ1 as elevated in colorectal cancer diagnosed before age 50, with CEMIP showing the strongest association with survival outcomes. (Genes) This content is informational only and does not constitute