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early-onset

A collection of 127 issues

CEMIP identified as candidate biomarker in early-onset colorectal cancer

Skip to content The CRC Digest ◇ RESEARCH CEMIP identified as candidate biomarker in early-onset colorectal cancer Researchers identified CEMIP as elevated in colorectal cancer diagnosed before age 50 and associated with poorer overall survival, with evidence linking it to PTCH1-related Hedgehog signaling pathways. (Genes) This content is informational only and

Real-World Study Characterizes Colorectal Neoplasia in Adults Under 50

Skip to content The CRC Digest Real-World Study Characterizes Colorectal Neoplasia in Adults Under 50 A single-center study of 152 patients aged 18-49 who underwent colonoscopy between 2018 and 2023 characterized the clinical, anatomical, and histopathological features of colorectal lesions in younger adults. (Journal of Clinical Medicine) This content is

CRC Research Update — August 27, 2026

Today's colorectal cancer research highlights

Lynch Syndrome Screening Performance Assessed in Early-Onset CRC Cohort

Skip to content The CRC Digest ◇ RESEARCH Lynch Syndrome Screening Performance Assessed in Early-Onset CRC Cohort The Padua study specifically evaluated mismatch repair testing and Lynch syndrome detection in early-onset CRC patients as part of a universal screening approach. (Cancers) This content is informational only and does not constitute medical

Universal Tumor Screening Evaluated for Lynch Syndrome Detection in 1,022 Consecutive CRC Cases

Skip to content The CRC Digest ▪ SCREENING Universal Tumor Screening Evaluated for Lynch Syndrome Detection in 1,022 Consecutive CRC Cases A University Hospital of Padua study assessed mismatch repair deficiency distribution and Lynch syndrome detection rates across clinical subgroups using immunohistochemistry-based universal tumor screening in consecutive surgical patients. (Cancers)

Genomic Analysis Reveals Distinct Mutation Patterns in Early-Onset vs. Average-Onset Metastatic CRC

Skip to content The CRC Digest ◇ RESEARCH Genomic Analysis Reveals Distinct Mutation Patterns in Early-Onset vs. Average-Onset Metastatic CRC A real-world next-generation sequencing study of 1,892 metastatic CRC patients found genomic differences between 376 early-onset cases (diagnosed before age 50) and 1,516 average-onset cases, potentially informing personalized treatment

SEER data shows 10,395 early-onset CRC cases in 2023

Skip to content The CRC Digest ▪ SCREENING SEER data shows 10,395 early-onset CRC cases in 2023 The study examined whether CRC incidence trends were concentrated among adults newly eligible for screening after the USPSTF lowered the recommended starting age from 50 to 45 years in 2021. (Am J Prev

Early-onset CRC incidence continues to rise in adults under 50

Skip to content The CRC Digest ▪ SCREENING Early-onset CRC incidence continues to rise in adults under 50 Analyzing SEER data from 2004-2023, researchers found 10,395 early-onset CRC cases in 2023, with incidence trends concentrated among adults aged 20-49 years, raising questions about screening strategies for those newly eligible under

Risk-Adapted Screening Strategy Shows Promise for Early-Onset CRC

Skip to content The CRC Digest ▪ SCREENING Risk-Adapted Screening Strategy Shows Promise for Early-Onset CRC A new study found that implementing a RAP-based risk-adapted screening strategy enables personalized screening initiation, with benefits comparable to those observed in the current 50-54-year age group. (Cancer Science) This content is informational only and

CRC Research Update — August 24, 2026

Today's colorectal cancer research highlights