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epidemiology

A collection of 22 issues

SEER data shows 10,395 early-onset CRC cases in 2023

Skip to content The CRC Digest ▪ SCREENING SEER data shows 10,395 early-onset CRC cases in 2023 The study examined whether CRC incidence trends were concentrated among adults newly eligible for screening after the USPSTF lowered the recommended starting age from 50 to 45 years in 2021. (Am J Prev

Early-onset CRC incidence continues to rise in adults under 50

Skip to content The CRC Digest ▪ SCREENING Early-onset CRC incidence continues to rise in adults under 50 Analyzing SEER data from 2004-2023, researchers found 10,395 early-onset CRC cases in 2023, with incidence trends concentrated among adults aged 20-49 years, raising questions about screening strategies for those newly eligible under

New model suggests accelerated colorectal carcinogenesis may limit screening effectiveness

Skip to content The CRC Digest ▪ SCREENING New model suggests accelerated colorectal carcinogenesis may limit screening effectiveness Researchers propose an exposure-driven accelerated carcinogenesis model to explain rising early-onset CRC, increasing distal and rectal tumors, and post-colonoscopy CRC despite high-quality screening, suggesting that current slowly progressive models may not fully capture

Traditional Risk Factors Not Linked to Early-Onset CRC Rise

Skip to content The CRC Digest Traditional Risk Factors Not Linked to Early-Onset CRC Rise A national cohort study using the All of Us Research Program found no significant association between traditional environmental risk factors or established genetic variants and the rising incidence of colorectal cancer in adults under age

Referral Center Reports Characteristics of Early-Onset CRC Patients

Skip to content The CRC Digest Referral Center Reports Characteristics of Early-Onset CRC Patients A retrospective cohort study of 56 patients under age 50 with colorectal cancer (median age 42 years) found the most frequent tumor location was the right colon. (Acta Gastroenterol Latinoam) This content is informational only and

Mexico sees marked increase in CRC among adults under 50

Skip to content The CRC Digest Mexico sees marked increase in CRC among adults under 50 A narrative review of epidemiological studies demonstrates a marked increase in CRC incidence and mortality in Mexico over the last two decades, with a disproportionate impact on adults under 50 years of age. (Cureus)

Significant discrepancies found in early-onset CRC among neglected populations

Skip to content The CRC Digest Significant discrepancies found in early-onset CRC among neglected populations A comprehensive review evaluating genetic and molecular research on hereditary and early-onset CRC in ethnic minority, indigenous, and understudied populations found significant discrepancies in early-onset CRC presentations compared with well-studied groups, despite largely consistent Lynch

Cancer Survivors Face Elevated Risk of Developing Colorectal Cancer

Skip to content The CRC Digest ♥ LIVING WITH CRC Cancer Survivors Face Elevated Risk of Developing Colorectal Cancer A Canadian cohort study of 172,928 non-colorectal cancer survivors found they have an elevated risk of developing subsequent primary colorectal cancers compared to the cancer-free population, suggesting tailored screening approaches may

Early-Onset CRC Among Young Latino Men Linked to Structural Inequities

Skip to content The CRC Digest Early-Onset CRC Among Young Latino Men Linked to Structural Inequities An editorial co-authored by a Latino cancer survivor diagnosed at age 38 examines how molecular epidemiology and structural inequities converge in early-onset colorectal cancer among young Latino men, who face diagnostic delays, lower screening

Symptom Identification Critical for Adults 18-44

Skip to content The CRC Digest Symptom Identification Critical for Adults 18-44 Adults under 45 without access to average-risk screening require a well-defined system for symptom identification and workup to avoid diagnostic delays and worse outcomes. (Cancer Epidemiology, Biomarkers & Prevention) This content is informational only and does not constitute