kras

Skip to content The CRC Digest Novel SOS1 Inhibitors Show Potent Activity Against KRAS-Driven CRC Highly potent and selective SOS1 inhibitors disrupted the SOS1-KRAS interaction, inhibited nucleotide exchange in wild-type and multiple KRAS variants, and showed submicromolar anti-proliferative activity in colorectal cancer cells. (J Med Chem) This content is informational