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lynch-syndrome

A collection of 50 issues

Lynch syndrome family shows MSI-H tumors despite preserved MMR protein staining

Skip to content The CRC Digest ◇ RESEARCH Lynch syndrome family shows MSI-H tumors despite preserved MMR protein staining A family carrying germline MLH1 c.931A>G presented with colorectal tumors showing retained mismatch repair protein expression by immunohistochemistry but microsatellite instability-high status on sequencing, highlighting that preserved staining does

CRC Research Update — September 11, 2026

Today's colorectal cancer research highlights

Lynch syndrome diagnosis rate in China far below expected prevalence

Skip to content The CRC Digest Lynch syndrome diagnosis rate in China far below expected prevalence A national survey of 81 physicians from 81 Chinese hospitals found a Lynch syndrome diagnosis rate of only 0.83% versus the expected 2-3%, despite 95.1% of hospitals offering dMMR immunohistochemistry. (Familial Cancer)

CRC Research Update — September 05, 2026

Today's colorectal cancer research highlights

Multigene Panel Testing Yield Quantified in Colorectal Cancer Patients

Skip to content The CRC Digest ◇ RESEARCH Multigene Panel Testing Yield Quantified in Colorectal Cancer Patients A systematic review and meta-analysis examined the diagnostic yield of germline multigene panel testing using next-generation sequencing in unselected patients with colorectal cancer, helping clarify how often inherited genetic factors contribute to diagnosis. (Lancet

First Colombian report of MUTYH-associated polyposis with novel mutations

Skip to content The CRC Digest ◇ RESEARCH First Colombian report of MUTYH-associated polyposis with novel mutations Case series from Colombia's Tolima Grande region describes individuals carrying pathogenic MUTYH variants c.452A>G and c.1353_1355del associated with polyposis phenotypes and colorectal cancer predisposition. (Frontiers in Oncology)

CRC Research Update — September 01, 2026

Today's colorectal cancer research highlights

Structured Surveillance in Lynch Syndrome Shows Effectiveness and Identifies Unmet Needs

Skip to content The CRC Digest Structured Surveillance in Lynch Syndrome Shows Effectiveness and Identifies Unmet Needs Retrospective analysis of 517 Lynch syndrome carriers undergoing structured multiorgan surveillance over 4,827 person-years reports cancer incidence rates, tumor distribution, and modes of detection to assess adherence and effectiveness of guideline-based follow-up.

CRC Research Update — August 28, 2026

Today's colorectal cancer research highlights

Lynch Syndrome Screening Performance Assessed in Early-Onset CRC Cohort

Skip to content The CRC Digest ◇ RESEARCH Lynch Syndrome Screening Performance Assessed in Early-Onset CRC Cohort The Padua study specifically evaluated mismatch repair testing and Lynch syndrome detection in early-onset CRC patients as part of a universal screening approach. (Cancers) This content is informational only and does not constitute medical