Prospective study examines MSI and CD8+ TILs in neoadjuvant chemotherapy response Skip to content The CRC Digest Prospective study examines MSI and CD8+ TILs in neoadjuvant chemotherapy response A prospective observational study investigated whether microsatellite instability, CD8+ tumor infiltrating lymphocytes expression, and chemotherapy response are related in colorectal cancer patients receiving neoadjuvant treatment. (Cancer Manag Res) This content is informational only
AZUR-4 Phase II trial tests neoadjuvant dostarlimab plus CAPEOX in MSS stage III colon cancer Skip to content The CRC Digest ◆ TRIAL DATA AZUR-4 Phase II trial tests neoadjuvant dostarlimab plus CAPEOX in MSS stage III colon cancer This randomized Phase II study compares neoadjuvant dostarlimab plus CAPEOX versus CAPEOX alone in previously untreated T4N0 or stage III mismatch repair proficient/microsatellite stable resectable colon
Total Neoadjuvant Therapy With Long-Course Radiotherapy Studied in High-Risk Rectal Cancer Skip to content The CRC Digest ◆ TRIAL DATA Total Neoadjuvant Therapy With Long-Course Radiotherapy Studied in High-Risk Rectal Cancer The multicenter phase III TNTCRT trial compared total neoadjuvant therapy using long-course radiotherapy versus chemoradiotherapy in patients with high-risk locally advanced rectal cancer. (Journal of Clinical Oncology) This content is informational
Dual immunotherapy shows promise in mismatch repair proficient colon cancer Skip to content The CRC Digest ◆ TRIAL DATA Dual immunotherapy shows promise in mismatch repair proficient colon cancer The phase 2 NEST trial tested neoadjuvant botensilimab plus balstilimab in patients with resectable colon cancer. The study examined safety, feasibility, and pathologic response before surgical resection. (Clinical Cancer Research) This content