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prospective

A collection of 92 issues

Liquid biopsy may redefine surgical decision-making in colorectal cancer

Skip to content The CRC Digest Liquid biopsy may redefine surgical decision-making in colorectal cancer A scoping review found that liquid biopsy offers a dynamic measure of tumor biology that complements pathological staging and guides postoperative management beyond conventional anatomy-based risk stratification. (Updates in Surgery) This content is informational only

Risk-Adapted Screening Strategy Shows Promise for Early-Onset CRC

Skip to content The CRC Digest ▪ SCREENING Risk-Adapted Screening Strategy Shows Promise for Early-Onset CRC A new study found that implementing a RAP-based risk-adapted screening strategy enables personalized screening initiation, with benefits comparable to those observed in the current 50-54-year age group. (Cancer Science) This content is informational only and

Sports Team Branding on Mailed Screening Kits Tested as Engagement Strategy

Skip to content The CRC Digest ▪ SCREENING Sports Team Branding on Mailed Screening Kits Tested as Engagement Strategy A randomized quality improvement study examined whether adding sports team branding and discount incentives to mailed colorectal cancer screening kits improved screening uptake. (Gastroenterology and Hepatology Advances) This content is informational only

Amino-acid biomarkers studied for Lynch syndrome surveillance

Skip to content The CRC Digest Amino-acid biomarkers studied for Lynch syndrome surveillance A prospective study is evaluating whether faecal and urinary amino-acids can help refine colonoscopy surveillance in individuals with Lynch syndrome, potentially reducing the burden of frequent screening. (International Journal of Cancer) This content is informational only and

Circulating tumor DNA dynamics predict survival in metastatic colorectal cancer

Skip to content The CRC Digest ◇ RESEARCH Circulating tumor DNA dynamics predict survival in metastatic colorectal cancer In a study of 1,391 patients, those with persistent or acquired RAS and BRAF mutations in ctDNA had significantly worse overall survival than patients who maintained wild-type status, suggesting liquid biopsy monitoring

New ctDNA assay validated for minimal residual disease monitoring across solid tumors

Skip to content The CRC Digest ◇ RESEARCH New ctDNA assay validated for minimal residual disease monitoring across solid tumors The Haystack MRD assay, a tumor-informed ctDNA test that tracks patient-specific somatic mutations, has been analytically and clinically validated across 23 solid tumor types for detecting minimal residual disease at low

ctDNA methylation profiling may predict prognosis beyond mutation testing

Skip to content The CRC Digest ◇ RESEARCH ctDNA methylation profiling may predict prognosis beyond mutation testing DNA methylation in circulating tumor DNA may provide additional prognostic information beyond mutation-based analysis by reflecting coordinated regulatory states associated with tumor behavior, including transcriptional programs and cellular plasticity. (Epigenomics) This content is informational

Risk-adapted FIT screening intervals may personalize colorectal cancer screening

Skip to content The CRC Digest ▪ SCREENING Risk-adapted FIT screening intervals may personalize colorectal cancer screening A modeling study based on the BLITZ cohort suggests that screening intervals for fecal immunochemical tests could be tailored based on quantitative hemoglobin levels in initially negative tests, stratifying participants into low, medium, and

FIT Performance Evaluated for Screening Younger Adults

Skip to content The CRC Digest FIT Performance Evaluated for Screening Younger Adults A multicutoff analysis examined how fecal immunochemical testing performs for colorectal cancer screening in people under 50. (Clinical Colorectal Cancer) This content is informational only and does not constitute medical advice. Always consult your oncologist or care

Prediagnostic Weight Loss May Explain the "Obesity Paradox" in CRC Survival

Skip to content The CRC Digest ♥ LIVING WITH CRC Prediagnostic Weight Loss May Explain the "Obesity Paradox" in CRC Survival A multicenter study of colorectal cancer patients found that cancer-associated weight loss before diagnosis may account for the apparent survival advantage seen in patients with elevated BMI at