Phase 3 ANCHOR trial compares anlotinib to bevacizumab plus chemotherapy in RAS/BRAF wild-type metastatic CRC Skip to content The CRC Digest ◆ TRIAL DATA Phase 3 ANCHOR trial compares anlotinib to bevacizumab plus chemotherapy in RAS/BRAF wild-type metastatic CRC This multicenter, randomized phase 3 trial evaluated first-line anlotinib versus bevacizumab plus CapeOX in patients with RAS/BRAF wild-type unresectable metastatic colorectal cancer. (Nature via Google
Final Analysis of DEEPER Trial in RAS/BRAF Wild-Type Metastatic CRC Skip to content The CRC Digest ◆ TRIAL DATA Final Analysis of DEEPER Trial in RAS/BRAF Wild-Type Metastatic CRC The DEEPER trial presents final analysis of long-term survival outcomes comparing modified-FOLFOXIRI plus cetuximab versus bevacizumab in patients with RAS and BRAF wild-type metastatic colorectal cancer. (Journal of Clinical Oncology) This
HER2-Targeted Therapy Gains Ground in Metastatic Colorectal Cancer with New Treatment Sequencing Guidance Skip to content The CRC Digest ▸ TREATMENT HER2-Targeted Therapy Gains Ground in Metastatic Colorectal Cancer with New Treatment Sequencing Guidance Narrative review outlines practical patient selection and treatment sequencing for HER2-targeted therapies in metastatic colorectal cancer, focusing on RAS wild-type disease with HER2 overexpression or ERBB2 amplification, including dual HER2
Final Analysis of DEEPER Trial Shows No Survival Difference Between Cetuximab and Bevacizumab in RAS/BRAF Wild-Type mCRC Skip to content The CRC Digest ◆ TRIAL DATA Final Analysis of DEEPER Trial Shows No Survival Difference Between Cetuximab and Bevacizumab in RAS/BRAF Wild-Type mCRC The phase II DEEPER trial found no differences in progression-free survival or overall survival in the per-protocol set when comparing modified-FOLFOXIRI plus cetuximab versus
Kazakhstani pilot study profiles KRAS and BRAF mutations using NGS and ddPCR Skip to content The CRC Digest Kazakhstani pilot study profiles KRAS and BRAF mutations using NGS and ddPCR Researchers used targeted next-generation sequencing and droplet digital PCR to characterize KRAS and BRAF mutations in metastatic colorectal cancer patients from Kazakhstan, where molecular epidemiological data remain limited. (Frontiers in Medicine) This