Phase II trial examines quality of life with panitumumab-based intensified regimen Skip to content The CRC Digest Phase II trial examines quality of life with panitumumab-based intensified regimen The VOLFI trial analyzed health-related quality of life in patients with RAS wild-type metastatic colorectal cancer treated with mFOLFOXIRI plus panitumumab versus FOLFOXIRI, noting that anti-EGFR antibodies like panitumumab are associated with a
Quality of life analysis from phase II VOLFI trial compares chemotherapy regimens in RAS wild-type metastatic disease Skip to content The CRC Digest ♥ LIVING WITH CRC Quality of life analysis from phase II VOLFI trial compares chemotherapy regimens in RAS wild-type metastatic disease A prespecified secondary analysis of the phase II VOLFI AIO-KRK 0109 trial examined quality of life in patients with RAS wild-type metastatic colorectal cancer
ctDNA-guided rechallenge with cetuximab plus irinotecan shows activity in RAS/BRAF wild-type mCRC Skip to content The CRC Digest ▸ TREATMENT ctDNA-guided rechallenge with cetuximab plus irinotecan shows activity in RAS/BRAF wild-type mCRC A Phase II trial enrolled patients with RAS/BRAF wild-type metastatic colorectal cancer who had progressed on prior cetuximab-based therapy, using circulating tumor DNA testing to select patients for rechallenge
Meta-analysis finds conflicting evidence on ctDNA RAS testing for anti-EGFR therapy Skip to content The CRC Digest ◇ RESEARCH Meta-analysis finds conflicting evidence on ctDNA RAS testing for anti-EGFR therapy A systematic review of patients with tissue RAS wild-type tumors receiving first-line chemotherapy plus anti-EGFR therapy found inconsistent results on whether ctDNA RAS status predicts outcomes, possibly due to differences in assay