RAS mutation linked to early progression in liver metastases conversion therapy Skip to content The CRC Digest RAS mutation linked to early progression in liver metastases conversion therapy Retrospective study of 194 patients with initially unresectable, pMMR colorectal liver metastases found that RAS mutation status was associated with early progression or recurrence after conversion therapy. (Front Surg) This content is informational
RAS and BRAF status in MSI-H/dMMR metastatic CRC Skip to content The CRC Digest RAS and BRAF status in MSI-H/dMMR metastatic CRC New guidance on the role of RAS and BRAF mutations in MSI-high and dMMR metastatic colorectal cancer. (Oncodaily) This content is informational only and does not constitute medical advice. Always consult your oncologist or care
CRC Research Finding Skip to content The CRC Digest ▸ Multi-omics deep learning model predicts anti-EGFR therapy response in liver metastases A multi-center study developed a deep learning framework integrating multi-omics data to predict which RAS wild-type colorectal cancer liver metastases patients will benefit from cetuximab therapy, addressing primary resistance challenges. (Curr Cancer Drug
KRAS G13C Inhibitor Reveals Unique Biology of Codon 13 Mutations Skip to content The CRC Digest KRAS G13C Inhibitor Reveals Unique Biology of Codon 13 Mutations RMC-8839, a covalent KRAS G13C inhibitor, induced tumor regressions in selected xenograft models, but one-third of cell lines showed incomplete pathway suppression, revealing that codon 13-mutant RAS differs from other KRAS mutations with decreased