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retrospective

A collection of 80 issues

Age-Stratified Mutation Patterns Reveal Distinct Features in Early-Onset CRC

Skip to content The CRC Digest ◇ RESEARCH Age-Stratified Mutation Patterns Reveal Distinct Features in Early-Onset CRC Analysis of 6,762 samples across four age groups found that early-onset colorectal cancer (diagnosed before age 50) shows different mutation patterns compared to later-onset disease, with implications for testing guidelines and therapeutic development.

Vietnamese Cohort Compares Early- vs Late-Onset CRC Outcomes

Skip to content The CRC Digest Vietnamese Cohort Compares Early- vs Late-Onset CRC Outcomes A retrospective study of 486 patients who underwent curative resection in Vietnam's Mekong Delta compared clinicopathologic features and survival between early-onset and late-onset colorectal cancer. (Arq Bras Cir Dig) This content is informational only

Patients With Poor Performance Status Still Benefit From Immunotherapy in MSI-H CRC

Skip to content The CRC Digest ▸ TREATMENT Patients With Poor Performance Status Still Benefit From Immunotherapy in MSI-H CRC An international retrospective study of dMMR/MSI-H metastatic colorectal cancer patients found that immune checkpoint blockers produced durable responses even in patients with poor ECOG performance status, a group often excluded

Immunotherapy Compared to Standard Care in MSS Metastatic CRC

Skip to content The CRC Digest ▸ TREATMENT Immunotherapy Compared to Standard Care in MSS Metastatic CRC A propensity-matched analysis of 708 chemorefractory patients compared immune checkpoint inhibitors to standard treatments like trifluridine/tipiracil in microsatellite stable metastatic colorectal cancer, though ICIs have limited efficacy in this population and selected patients

Case series from Tanzania documents colorectal cancer in patients under 30

Skip to content The CRC Digest ♥ LIVING WITH CRC Case series from Tanzania documents colorectal cancer in patients under 30 Three patients under age 30 presented with advanced disease after prolonged symptoms including rectal bleeding and weight loss; two had mucinous adenocarcinoma and one had a family history suggesting hereditary

First Colombian report of MUTYH-associated polyposis with novel mutations

Skip to content The CRC Digest ◇ RESEARCH First Colombian report of MUTYH-associated polyposis with novel mutations Case series from Colombia's Tolima Grande region describes individuals carrying pathogenic MUTYH variants c.452A>G and c.1353_1355del associated with polyposis phenotypes and colorectal cancer predisposition. (Frontiers in Oncology)

PET/CT metabolic parameters predict microsatellite instability status in colorectal cancer

Skip to content The CRC Digest PET/CT metabolic parameters predict microsatellite instability status in colorectal cancer Researchers developed a non-invasive nomogram model using preoperative 18F-FDG PET/CT metabolic parameters to predict MSI status in 156 CRC patients, potentially guiding personalized treatment decisions. (Rev Esp Med Nucl Imagen Mol) This

Whole-Genome Electrical Impedance Assay Detects DNA Hypomethylation for CRC Screening

Skip to content The CRC Digest ▪ SCREENING Whole-Genome Electrical Impedance Assay Detects DNA Hypomethylation for CRC Screening A rapid, label-free cell-free DNA assay measures global DNA hypomethylation—a hallmark of colorectal cancer—using electrical impedance to differentiate healthy individuals from those with cancer in a retrospective validation study. (Computational and

Age-stratified analysis reveals CEMIP elevation in early-onset CRC

Skip to content The CRC Digest ◇ RESEARCH Age-stratified analysis reveals CEMIP elevation in early-onset CRC Transcriptomic profiling identified CEMIP, NKD2, and FOXQ1 as elevated in colorectal cancer diagnosed before age 50, with CEMIP showing the strongest association with survival outcomes. (Genes) This content is informational only and does not constitute

CEMIP identified as candidate biomarker in early-onset colorectal cancer

Skip to content The CRC Digest ◇ RESEARCH CEMIP identified as candidate biomarker in early-onset colorectal cancer Researchers identified CEMIP as elevated in colorectal cancer diagnosed before age 50 and associated with poorer overall survival, with evidence linking it to PTCH1-related Hedgehog signaling pathways. (Genes) This content is informational only and