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screening-procedure

A collection of 109 issues

Structured Surveillance in Lynch Syndrome Shows Effectiveness and Identifies Unmet Needs

Skip to content The CRC Digest Structured Surveillance in Lynch Syndrome Shows Effectiveness and Identifies Unmet Needs Retrospective analysis of 517 Lynch syndrome carriers undergoing structured multiorgan surveillance over 4,827 person-years reports cancer incidence rates, tumor distribution, and modes of detection to assess adherence and effectiveness of guideline-based follow-up.

Scoping Review Identifies Barriers to Diagnostic Colonoscopy After Positive Stool-Based Screening

Skip to content The CRC Digest ▪ SCREENING Scoping Review Identifies Barriers to Diagnostic Colonoscopy After Positive Stool-Based Screening Systematic review synthesizes barriers and facilitators to completing diagnostic colonoscopy after a positive non-invasive stool-based screening test (FIT, gFOBT, or multitarget stool DNA), emphasizing that timely follow-up colonoscopy is essential for reducing

Australian audit finds gaps in surveillance colonoscopy guideline adherence

Skip to content The CRC Digest ▪ SCREENING Australian audit finds gaps in surveillance colonoscopy guideline adherence A clinical audit of six Victorian public hospitals assessed concordance of endoscopist-recommended surveillance colonoscopy intervals with 2018 Australian Cancer Council guidelines, identifying opportunities to improve adherence. (Australian Health Review) This content is informational only

Genetic Risk Stratification Identifies High Adenoma Detection Rates at Colonoscopy

Skip to content The CRC Digest ▪ SCREENING Genetic Risk Stratification Identifies High Adenoma Detection Rates at Colonoscopy A retrospective study of 800 adults from a US health-system biobank who underwent colonoscopy between 2010 and 2025 found that inherited genetic risk may improve yield of adenoma detection and prioritization of colonoscopy

Blood Test Combining cfDNA Fragmentomics and Methylation Markers Detects Precancerous Lesions

Skip to content The CRC Digest ▪ SCREENING Blood Test Combining cfDNA Fragmentomics and Methylation Markers Detects Precancerous Lesions A study of 380 CRC patients, 121 individuals with precancerous lesions, and 506 healthy controls found that adding methylation analysis of SEPT9 and HS3ST2 to cfDNA fragmentomic features improved detection of precancerous

Lynch Syndrome Screening Performance Assessed in Early-Onset CRC Cohort

Skip to content The CRC Digest ◇ RESEARCH Lynch Syndrome Screening Performance Assessed in Early-Onset CRC Cohort The Padua study specifically evaluated mismatch repair testing and Lynch syndrome detection in early-onset CRC patients as part of a universal screening approach. (Cancers) This content is informational only and does not constitute medical

Universal Tumor Screening Evaluated for Lynch Syndrome Detection in 1,022 Consecutive CRC Cases

Skip to content The CRC Digest ▪ SCREENING Universal Tumor Screening Evaluated for Lynch Syndrome Detection in 1,022 Consecutive CRC Cases A University Hospital of Padua study assessed mismatch repair deficiency distribution and Lynch syndrome detection rates across clinical subgroups using immunohistochemistry-based universal tumor screening in consecutive surgical patients. (Cancers)

CONFIRM trial examines race, ethnicity, and screening test use among Veterans

Skip to content The CRC Digest ▪ SCREENING CONFIRM trial examines race, ethnicity, and screening test use among Veterans A study of 50,125 US Veteran participants in a randomized trial comparing colonoscopy to annual fecal immunochemical testing examined how race, ethnicity, and access to care factors relate to screening test

SEER data shows 10,395 early-onset CRC cases in 2023

Skip to content The CRC Digest ▪ SCREENING SEER data shows 10,395 early-onset CRC cases in 2023 The study examined whether CRC incidence trends were concentrated among adults newly eligible for screening after the USPSTF lowered the recommended starting age from 50 to 45 years in 2021. (Am J Prev

Gut microbiome profiles improve detection of precancerous lesions in FIT screening

Skip to content The CRC Digest ▪ SCREENING Gut microbiome profiles improve detection of precancerous lesions in FIT screening In a Norwegian study of 1,034 FIT-positive screening participants, combining microbial profiles with quantitative FIT values improved detection of premalignant lesions beyond optimizing the FIT value alone. (Nat Commun) This content