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screening-procedure

A collection of 109 issues

Early-onset CRC incidence continues to rise in adults under 50

Skip to content The CRC Digest ▪ SCREENING Early-onset CRC incidence continues to rise in adults under 50 Analyzing SEER data from 2004-2023, researchers found 10,395 early-onset CRC cases in 2023, with incidence trends concentrated among adults aged 20-49 years, raising questions about screening strategies for those newly eligible under

New model suggests accelerated colorectal carcinogenesis may limit screening effectiveness

Skip to content The CRC Digest ▪ SCREENING New model suggests accelerated colorectal carcinogenesis may limit screening effectiveness Researchers propose an exposure-driven accelerated carcinogenesis model to explain rising early-onset CRC, increasing distal and rectal tumors, and post-colonoscopy CRC despite high-quality screening, suggesting that current slowly progressive models may not fully capture

Blood-Based Screening Now Available Starting at Age 45

Skip to content The CRC Digest Blood-Based Screening Now Available Starting at Age 45 The newly FDA-approved SimpleScreen CRC blood test is available for adults aged 45 years and older who are at average risk for colorectal cancer. (The ASCO Post) This content is informational only and does not constitute

Risk-Adapted Screening Strategy Shows Promise for Early-Onset CRC

Skip to content The CRC Digest ▪ SCREENING Risk-Adapted Screening Strategy Shows Promise for Early-Onset CRC A new study found that implementing a RAP-based risk-adapted screening strategy enables personalized screening initiation, with benefits comparable to those observed in the current 50-54-year age group. (Cancer Science) This content is informational only and

Adding Chemotherapy to Immunotherapy May Extend Survival in MSI-H Metastatic CRC

Skip to content The CRC Digest ◆ TRIAL DATA Adding Chemotherapy to Immunotherapy May Extend Survival in MSI-H Metastatic CRC The phase III NRG-GI004/SWOG S1610 COMMIT trial found that combining mFOLFOX6, bevacizumab, and atezolizumab may prolong progression-free survival over atezolizumab alone in first-line treatment of mismatch repair–deficient/microsatellite instability–

FDA Approves SimpleScreen CRC Blood Test for Average-Risk Adults

Skip to content The CRC Digest ● REGULATORY FDA Approves SimpleScreen CRC Blood Test for Average-Risk Adults The FDA has approved SimpleScreen CRC, a new blood-based screening option for colorectal cancer in adults aged 45 and older at average risk, based on data from the PREEMPT CRC trial. (The ASCO Post)

Sports Team Branding on Mailed Screening Kits Tested as Engagement Strategy

Skip to content The CRC Digest ▪ SCREENING Sports Team Branding on Mailed Screening Kits Tested as Engagement Strategy A randomized quality improvement study examined whether adding sports team branding and discount incentives to mailed colorectal cancer screening kits improved screening uptake. (Gastroenterology and Hepatology Advances) This content is informational only

Amino-acid biomarkers studied for Lynch syndrome surveillance

Skip to content The CRC Digest Amino-acid biomarkers studied for Lynch syndrome surveillance A prospective study is evaluating whether faecal and urinary amino-acids can help refine colonoscopy surveillance in individuals with Lynch syndrome, potentially reducing the burden of frequent screening. (International Journal of Cancer) This content is informational only and

PharmFIT trial tests pharmacy-based colorectal cancer screening

Skip to content The CRC Digest ▪ SCREENING PharmFIT trial tests pharmacy-based colorectal cancer screening A two-arm, pragmatic, hybrid type 1 effectiveness-implementation trial is underway in Washington and North Carolina to evaluate whether community pharmacies can expand access to FIT screening for underserved patients due for colorectal cancer screening. (Contemporary Clinical

Inadequate bowel prep obscures polyps and early cancer signs, increases costs

Skip to content The CRC Digest ▪ SCREENING Inadequate bowel prep obscures polyps and early cancer signs, increases costs A new guideline emphasizes that inadequate bowel preparation can obscure polyps, lesions, or early signs of colorectal cancer while increasing procedure length and shortening surveillance intervals; experts recommend aiming for adequate prep