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systematic-review

A collection of 36 issues

Gut microbiome may influence resistance to immunotherapy in MSI-H/dMMR colorectal cancer

Skip to content The CRC Digest ◇ RESEARCH Gut microbiome may influence resistance to immunotherapy in MSI-H/dMMR colorectal cancer A narrative review summarizes evidence that the gut microbiome-immune axis regulates antitumor immunity and may mediate both primary and acquired resistance to immune checkpoint inhibitors in MSI-H/dMMR CRC. (Front Cell

Critical review outlines biomarker-guided treatment selection in metastatic CRC

Skip to content The CRC Digest Critical review outlines biomarker-guided treatment selection in metastatic CRC A structured narrative review separately examines mismatch repair-deficient/MSI-H and microsatellite-stable disease, distinguishing established treatments from investigational strategies based on molecular alterations including BRAF V600E and HER2. (Crit Rev Oncol Hematol) This content is informational

Screening strategies may not adequately address early-onset CRC burden

Skip to content The CRC Digest Screening strategies may not adequately address early-onset CRC burden A systematic review found uncertainty remains regarding whether current screening strategies adequately address the diagnostic burden of early-onset colorectal cancer, defined as diagnosis before age 50. (Cancer Epidemiol) This content is informational only and does

Systematic review finds screening gaps in early-onset colorectal cancer despite lowered age thresholds

Skip to content The CRC Digest ▪ SCREENING Systematic review finds screening gaps in early-onset colorectal cancer despite lowered age thresholds A systematic review of population-based screening studies found that current strategies may not adequately address the diagnostic burden of colorectal cancer in adults younger than 50, even as several countries

Review examines why microsatellite-stable tumors resist immunotherapy

Skip to content The CRC Digest ◇ RESEARCH Review examines why microsatellite-stable tumors resist immunotherapy A systematic review found that mismatch repair-proficient, microsatellite stable tumors remain resistant to immunotherapy due to low neoantigen load, defects in antigen presentation, and Wnt/β-catenin pathway activity that reduce immune recognition and T-cell infiltration. (Molecules)

Scoping Review Maps Global Variation in Early-Onset CRC Patterns

Skip to content The CRC Digest Scoping Review Maps Global Variation in Early-Onset CRC Patterns A scoping review of studies published 2019–2024 synthesized contemporary evidence on epidemiologic, molecular, and survival differences in early-onset colorectal cancer across regions and racial/ethnic groups. (Journal of Gastrointestinal Cancer) This content is informational

Cytokines May Modulate Checkpoint Inhibitor Response in MSI-H CRC

Skip to content The CRC Digest ◇ RESEARCH Cytokines May Modulate Checkpoint Inhibitor Response in MSI-H CRC A review highlights how cytokines can critically modulate immune checkpoint inhibitor effectiveness in mismatch repair-deficient/microsatellite instability-high colorectal cancer by influencing checkpoint expression and shaping the tumor microenvironment. (Critical Reviews in Oncology/Hematology) This

Multigene Panel Testing Yield Quantified in Colorectal Cancer Patients

Skip to content The CRC Digest ◇ RESEARCH Multigene Panel Testing Yield Quantified in Colorectal Cancer Patients A systematic review and meta-analysis examined the diagnostic yield of germline multigene panel testing using next-generation sequencing in unselected patients with colorectal cancer, helping clarify how often inherited genetic factors contribute to diagnosis. (Lancet

Roadmap for early-onset colorectal cancer prevention highlights lifestyle factors and emerging risk pathways

Skip to content The CRC Digest Roadmap for early-onset colorectal cancer prevention highlights lifestyle factors and emerging risk pathways Review identifies obesity, metabolic conditions, poor diet, and sedentary behavior as key EOCRC risk factors, with growing evidence for early-life and gut microbial exposures. (Nature Reviews Cancer) This content is informational

Scoping Review Identifies Barriers to Diagnostic Colonoscopy After Positive Stool-Based Screening

Skip to content The CRC Digest ▪ SCREENING Scoping Review Identifies Barriers to Diagnostic Colonoscopy After Positive Stool-Based Screening Systematic review synthesizes barriers and facilitators to completing diagnostic colonoscopy after a positive non-invasive stool-based screening test (FIT, gFOBT, or multitarget stool DNA), emphasizing that timely follow-up colonoscopy is essential for reducing