Sign in Subscribe

under-50

A collection of 94 issues

Screening Age Thresholds Miss Early-Onset CRC Risk Established in Youth

Skip to content The CRC Digest Screening Age Thresholds Miss Early-Onset CRC Risk Established in Youth A new analysis argues that age-based screening creates a "blind spot" for early-onset colorectal cancer because high-risk states may be established through early-life exposures decades before screening begins at age 45. (Frontiers

CRC Research Update — September 01, 2026

Today's colorectal cancer research highlights

CRC Research Update — August 31, 2026

Today's colorectal cancer research highlights

Roadmap for early-onset colorectal cancer prevention highlights lifestyle factors and emerging risk pathways

Skip to content The CRC Digest Roadmap for early-onset colorectal cancer prevention highlights lifestyle factors and emerging risk pathways Review identifies obesity, metabolic conditions, poor diet, and sedentary behavior as key EOCRC risk factors, with growing evidence for early-life and gut microbial exposures. (Nature Reviews Cancer) This content is informational

CRC Research Update — August 30, 2026

Today's colorectal cancer research highlights

Genomic Differences Between Early-Onset and Average-Onset Metastatic CRC Identified

Skip to content The CRC Digest ◇ RESEARCH Genomic Differences Between Early-Onset and Average-Onset Metastatic CRC Identified A real-world next-generation sequencing study compared the genomic landscape of early-onset colorectal cancer with average-onset metastatic disease, identifying distinct molecular features in younger patients. (JCO Precision Oncology) This content is informational only and does

Age-stratified analysis reveals CEMIP elevation in early-onset CRC

Skip to content The CRC Digest ◇ RESEARCH Age-stratified analysis reveals CEMIP elevation in early-onset CRC Transcriptomic profiling identified CEMIP, NKD2, and FOXQ1 as elevated in colorectal cancer diagnosed before age 50, with CEMIP showing the strongest association with survival outcomes. (Genes) This content is informational only and does not constitute

CEMIP identified as candidate biomarker in early-onset colorectal cancer

Skip to content The CRC Digest ◇ RESEARCH CEMIP identified as candidate biomarker in early-onset colorectal cancer Researchers identified CEMIP as elevated in colorectal cancer diagnosed before age 50 and associated with poorer overall survival, with evidence linking it to PTCH1-related Hedgehog signaling pathways. (Genes) This content is informational only and

Real-World Study Characterizes Colorectal Neoplasia in Adults Under 50

Skip to content The CRC Digest Real-World Study Characterizes Colorectal Neoplasia in Adults Under 50 A single-center study of 152 patients aged 18-49 who underwent colonoscopy between 2018 and 2023 characterized the clinical, anatomical, and histopathological features of colorectal lesions in younger adults. (Journal of Clinical Medicine) This content is

CRC Research Update — August 27, 2026

Today's colorectal cancer research highlights