MSI-H and mismatch repair-deficient cancers show dependence on Werner syndrome RecQ helicase (WRN), a synthetic-lethal vulnerability linked to expanded TA-dinucleotide repeats and replication-associated genome instability, though dependency is not universal among all MSI-H tumors. (Front Pharmacol)
WRN helicase emerges as therapeutic target in MSI-H colorectal cancer
The CRC Digest