Sign in Subscribe

Alex Chompff

Machine Learning Model Combines FIT with Clinical Data to Triage Fast-Track Colonoscopy Referrals

Skip to content The CRC Digest ▪ SCREENING Machine Learning Model Combines FIT with Clinical Data to Triage Fast-Track Colonoscopy Referrals Swedish researchers developed and externally validated risk models combining faecal immunochemical test results with age, sex, symptoms, and imaging to prioritize 2,539 fast-track colonoscopies, aiming to improve endoscopy capacity.

Three Distinct Activity Profiles Identified in CRC Survivors Shortly After Treatment

Skip to content The CRC Digest ◇ RESEARCH Three Distinct Activity Profiles Identified in CRC Survivors Shortly After Treatment Accelerometer data from 358 colorectal cancer patients revealed three activity profiles: most sedentary (16%), average (53%), and highly active (31%). (J Cancer Surviv) This content is informational only and does not constitute

CRC Research Update — September 07, 2026

Today's colorectal cancer research highlights

Fruquintinib plus immunotherapy evaluated in MSS refractory mCRC

Skip to content The CRC Digest Fruquintinib plus immunotherapy evaluated in MSS refractory mCRC A retrospective study of 145 patients with microsatellite-stable metastatic CRC who had progressed after at least two systemic treatment lines aimed to evaluate whether fruquintinib alone, fruquintinib plus a PD-1 inhibitor, or the combination with radiotherapy

Hospitalization outcomes differ between early- and late-onset CRC patients

Skip to content The CRC Digest Hospitalization outcomes differ between early- and late-onset CRC patients A national database study (2016-2020) compared hospitalization trends and outcomes in patients diagnosed before age 50 versus those 50 and older, finding distinct patterns in mortality, length of stay, and associations with obesity and sociodemographic

Dietary and metabolic risk factors drive rising early-onset CRC rates in the U.S.

Skip to content The CRC Digest ♥ LIVING WITH CRC Dietary and metabolic risk factors drive rising early-onset CRC rates in the U.S. A 33-year analysis of Global Burden of Disease data shows that while traditional colorectal cancer rates in older adults have declined, early-onset cases (diagnosed under age 50)

Meta-analysis finds conflicting evidence on ctDNA RAS testing for anti-EGFR therapy

Skip to content The CRC Digest ◇ RESEARCH Meta-analysis finds conflicting evidence on ctDNA RAS testing for anti-EGFR therapy A systematic review of patients with tissue RAS wild-type tumors receiving first-line chemotherapy plus anti-EGFR therapy found inconsistent results on whether ctDNA RAS status predicts outcomes, possibly due to differences in assay

Tracking ctDNA after surgery identifies high-risk patients despite negative MRD status

Skip to content The CRC Digest ◇ RESEARCH Tracking ctDNA after surgery identifies high-risk patients despite negative MRD status A longitudinal study of 124 stage II-III patients found that analyzing circulating tumor DNA (ctDNA) trajectories after surgery can identify subgroups at high risk for recurrence or metastasis, even when initial minimal

COMMIT trial analysis examines chemoimmunotherapy in dMMR metastatic CRC

Skip to content The CRC Digest ◆ TRIAL DATA COMMIT trial analysis examines chemoimmunotherapy in dMMR metastatic CRC A new analysis explores what the COMMIT trial can and cannot tell us about combining chemotherapy with immunotherapy in patients with deficient DNA mismatch repair metastatic colorectal cancer. (Journal of Clinical Oncology) This

CRC Research Update — September 06, 2026

Today's colorectal cancer research highlights