CRC Research Update — September 19, 2026
Today's colorectal cancer research highlights
Alex Chompff
Pathological complete response to pembrolizumab in dMMR CRC despite radiological residual disease
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The CRC Digest
Pathological complete response to pembrolizumab in dMMR CRC despite radiological residual disease
A case report describes a 70-year-old man with dMMR sigmoid colon cancer and liver metastases who achieved pathological complete response in both primary and metastatic lesions after preoperative pembrolizumab, despite imaging suggesting
Machine learning models tested for mortality prediction in Tennessee early-onset CRC patients
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The CRC Digest
Machine learning models tested for mortality prediction in Tennessee early-onset CRC patients
A retrospective study of 3,467 Tennessee patients aged 20–49 compared machine learning algorithms for predicting all-cause mortality and 1-, 3-, and 5-year mortality. (Cancer Epidemiol)
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German trial to test invitation strategies for CRC screening in adults under 50
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The CRC Digest
German trial to test invitation strategies for CRC screening in adults under 50
The PETER trial will assess the effect of postal and digital invitations and reminders on faecal immunochemical test use and early detection among younger adults. (BMJ Open)
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Tumor mutational burden studied as prognostic marker in metastatic CRC receiving immunotherapy
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The CRC Digest
◇ RESEARCH
Tumor mutational burden studied as prognostic marker in metastatic CRC receiving immunotherapy
A retrospective cohort study of 221 metastatic CRC patients receiving anti-PD-1/PD-L1 immunotherapy plus chemotherapy assessed tumor mutational burden as a biomarker for survival and quality of life outcomes. (Medicine)
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Newer colonoscope models and texture enhancement imaging improve adenoma detection
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The CRC Digest
▪ SCREENING
Newer colonoscope models and texture enhancement imaging improve adenoma detection
Analysis of 28,459 colonoscopies aimed to identify clinical and technological factors most strongly associated with increased adenoma detection rate, including newer colonoscope models and texture and color enhancement imaging. (Scand J Gastroenterol)
Study assesses impact of concurrent palliative care on metastatic CRC patients on systemic therapy
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The CRC Digest
♥ LIVING WITH CRC
Study assesses impact of concurrent palliative care on metastatic CRC patients on systemic therapy
A retrospective study of 201 metastatic CRC patients assessed the impact of concurrent multidisciplinary palliative care alongside systemic therapy on patient-reported outcomes and healthcare utilization. (Front Oncol)
Gut microbiome may influence resistance to immunotherapy in MSI-H/dMMR colorectal cancer
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The CRC Digest
◇ RESEARCH
Gut microbiome may influence resistance to immunotherapy in MSI-H/dMMR colorectal cancer
A narrative review summarizes evidence that the gut microbiome-immune axis regulates antitumor immunity and may mediate both primary and acquired resistance to immune checkpoint inhibitors in MSI-H/dMMR CRC. (Front Cell
CRC Research Update — September 18, 2026
Today's colorectal cancer research highlights
Pulmonary artery enlargement observed during bevacizumab therapy in KRAS-mutant colon cancer
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The CRC Digest
Pulmonary artery enlargement observed during bevacizumab therapy in KRAS-mutant colon cancer
A retrospective study of 150 patients with KRAS-mutant colon cancer investigated whether serial thoracic CT demonstrates progressive enlargement of the main pulmonary artery during bevacizumab-based chemotherapy. (Cancer Chemother Pharmacol)
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