Chemotherapy-induced apoptotic cell overload drives formation of tumor-suppressive multinucleated giant cells

◇ RESEARCH

Researchers found that excessive apoptotic cell burden after neoadjuvant chemotherapy activates the TREM2/TYROBP-MAPK pathway, promoting macrophage fusion into multinucleated giant cells that inhibit tumor growth and reshape the immune microenvironment in preclinical models. (Cell Death Dis)