RESEARCH
Multiomic profiling identifies FAK, PDK, and proteasome as therapeutic targets in RAS-mutant MSS colorectal cancerAnalysis of approximately 2,000 tumor samples and 195,246 single cells revealed that focal adhesion kinase, phosphoinositide-dependent kinase, and proteasome inhibition combined with MEK blockade showed activity in patient-derived models of RAS-mutant microsatellite-stable colorectal cancer. (Cancer Cell)